Synthesis of labelled dihydroartemisinic acid

被引：17

作者：

Brown, GD

Sy, LK

机构：

[1] Univ Reading, Sch Chem, Reading RG6 6AD, Berks, England

[2] Univ Hong Kong, Dept Chem, Hong Kong, Hong Kong, Peoples R China

[3] Univ Hong Kong, Area Excellence Scheme Univ Grant Comm, Open Lab Chem Biol, Inst Mol Technol Drug Discovery & Synth, Hong Kong, Hong Kong, Peoples R China

来源：

TETRAHEDRON | 2004年 / 60卷 / 05期

关键词：

terpenes and terpenoids; labelling; isotope effects; NMR;

D O I：

10.1016/j.tet.2003.11.069

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[15-(CH3)-C-13-H-2]-Dihydroartemisinic acid (2a), [15-(CH3)-H-2]-dihydroartemisinic acid (2b) and [15-(CH3)-C-13]-dihydroartemisinic acid (2c) have been obtained in good yield and high isotopic enrichment by a reconstructive synthesis from artemisinin. These labelled compounds were designed to be used in biosynthetic experiments to determine the origins of artemisinin and other sesquiterpene natural products from Artemisia annua. (C) 2003 Elsevier Ltd. All rights reserved.

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收藏

页码：1125 / 1138

页数：14

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