Experimental evaluation of second-line oral treatments of visceral leishmaniasis caused by Leishmania infantum

被引：48

作者：

Gangneux, JP ^{[1
]}

Dullin, M ^{[1
]}

Sulahian, A ^{[1
]}

Garin, YJF ^{[1
]}

Derouin, F ^{[1
]}

机构：

[1] Fac Med Lariboisiere St Louis, Lab Parasitol Mycol, F-75270 Paris 06, France

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1999年 / 43卷 / 01期

关键词：

D O I：

10.1128/AAC.43.1.172

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In a murine model of Leishmania infantum visceral leishmaniasis, metronidazole, ketoconazole, fluconazole, itraconazole, and terbinafine were less effective than antimonial agents in reducing hepatic parasite load. Ketoconazole potentiated the effect of meglumine antimoniate reference therapy through its marked activity against spleen infection.

引用

页码：172 / 174

页数：3

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