Experimental evaluation of second-line oral treatments of visceral leishmaniasis caused by Leishmania infantum

被引：48

作者：

Gangneux, JP ^{[1
]}

Dullin, M ^{[1
]}

Sulahian, A ^{[1
]}

Garin, YJF ^{[1
]}

Derouin, F ^{[1
]}

机构：

[1] Fac Med Lariboisiere St Louis, Lab Parasitol Mycol, F-75270 Paris 06, France

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1999年 / 43卷 / 01期

关键词：

D O I：

10.1128/AAC.43.1.172

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In a murine model of Leishmania infantum visceral leishmaniasis, metronidazole, ketoconazole, fluconazole, itraconazole, and terbinafine were less effective than antimonial agents in reducing hepatic parasite load. Ketoconazole potentiated the effect of meglumine antimoniate reference therapy through its marked activity against spleen infection.

引用

页码：172 / 174

页数：3

共 31 条

[21] Failure of a combination of two antifungal drugs, terbinafine plus itraconazole, in Sudanese post kala-azar dermal leishmaniasis [J].

Khalil, EAG ;

Nur, NM ;

Zijlstra, EE ;

ElHassan, AM ;

Davidson, RN .

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1996, 90 (02) :187-188

[22] MAINTENANCE ITRACONAZOLE FOR VISCERAL LEISHMANIASIS IN HIV-INFECTION [J].

LAFEUILLADE, A ;

CHAFFANJON, P ;

DELBEKE, E ;

QUILICHINI, R .

AMERICAN JOURNAL OF MEDICINE, 1992, 92 (04) :449-449

[23]

Mbongo N, 1998, ANTIMICROB AGENTS CH, V42, P352

[24] METRONIDAZOLE AND INDIAN KALA-AZAR - RESULTS OF A CLINICAL-TRIAL [J].

MISHRA, M ;

THAKUR, BD ;

CHOUDHARY, M .

BRITISH MEDICAL JOURNAL, 1985, 291 (6509) :1611-1611

[25] PLACEBO-CONTROLLED CLINICAL-TRIAL OF SODIUM STIBOGLUCONATE (PENTOSTAM) VERSUS KETOCONAZOLE FOR TREATING CUTANEOUS LEISHMANIASIS IN GUATEMALA [J].

NAVIN, TR ;

ARANA, BA ;

ARANA, FE ;

BERMAN, JD ;

CHAJON, JF .

JOURNAL OF INFECTIOUS DISEASES, 1992, 165 (03) :528-534

[26] USE OF AN ITRACONAZOLE/ALLOPURINOL COMBINATION FOR THE TREATMENT OF VISCERAL LEISHMANIASIS IN A PATIENT WITH AIDS [J].

RAFFI, F ;

MERRIEN, D ;

LEPAPE, P ;

RELIQUET, V .

CLINICAL INFECTIOUS DISEASES, 1995, 21 (05) :1338-1339

[27] EFFICACY OF KETOCONAZOLE AGAINST LEISHMANIA-BRAZILIENSIS-PANAMENSIS CUTANEOUS LEISHMANIASIS [J].

SAENZ, RE ;

PAZ, H ;

BERMAN, JD .

AMERICAN JOURNAL OF MEDICINE, 1990, 89 (02) :147-155

[28]

THAKUR CP, 1989, J TROP MED HYG, V92, P383

[29] Fluconazole plus allopurinol in treatment of visceral leishmaniasis [J].

Torrus, D ;

Boix, V ;

Massa, B ;

Portilla, J ;

PerezMateo, M .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1996, 37 (05) :1042-1043

[30] KETOCONAZOLE IN THE TREATMENT OF ANTIMONY-RESISTANT AND PENTAMIDINE-RESISTANT KALA-AZAR [J].

WALI, JP ;

AGGARWAL, P ;

GUPTA, U ;

SALUJA, S ;

SINGH, S .

JOURNAL OF INFECTIOUS DISEASES, 1992, 166 (01) :215-216

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