Primary pulmonary MALT lymphomas show frequent and heterogeneous cytogenetic abnormalities, including aneuploidy and translocations involving API2 and MALT1 and IGH and MALT1

被引:53
作者
Remstein, ED
Kurtin, PJ
Einerson, RR
Paternoster, SF
Dewald, GW
机构
[1] Mayo Clin & Mayo Fdn, Div Anat Pathol, Rochester, MN 55905 USA
[2] Mayo Clin & Mayo Fdn, Div Hematopathol, Rochester, MN 55905 USA
[3] Mayo Clin & Mayo Fdn, Div Lab Genet, Rochester, MN 55905 USA
关键词
MALT lymphoma; IGH-MALT1; t(14; 18); t(11; FISH; cytogenetics;
D O I
10.1038/sj.leu.2403185
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
API2-MALT1 fusion and aneuploidy are common chromosomal abnormalities in MALT lymphoma. In studying their incidence and relationship in primary pulmonary MALT lymphomas, a translocation involving MALT1 and IGH was also identified. In all, 28 primary pulmonary MALT lymphomas were studied by fluorescence in situ hybridization using an API2-MALT1 probe and multiple centromeric probes, as well as IGH-BCL2, IGH-MALT1, and MALT1 breakapart probes in selected cases. Seven (25%) had API2-MALT1 fusion; all seven lacked aneuploidy except for two with trisomy 3 in a small clone. Three (11%) had IGH-MALT1 fusion; two also showed trisomy 3 and 12. A total of 11 (39%) had aneuploidy only, with trisomy 3 and 18 being the most common. Ectopic nuclear bcl-10 expression, which has been previously associated with API2-MALT1, was seen by immunohistochemistry in 86% of API2-MALT1 fusion-positive cases, one IGH-MALT1 fusion-positive case, two aneuploidy-only cases, and two normal cases. In primary pulmonary MALT lymphomas, cytogenetic abnormalities are common (75%) and heterogeneous, encompassing API2-MALT1 and IGH-MALT1, which are mutually exclusive, as well as aneuploidy, which may be present in the latter but is rare in the former. Ectopic nuclear bcl-10 expression is associated with API2-MALT1 but may also be seen in IGH-MALT1 fusion-positive, aneuploidy-only, and normal cases.
引用
收藏
页码:156 / 160
页数:5
相关论文
共 33 条
[1]  
Abe K, 1996, ACTA OTO-LARYNGOL, P259
[2]   BCL10 in malignant lymphomas -: an evaluation using fluorescence in situ hybridization [J].
Achuthan, R ;
Bell, SM ;
Carr, IM ;
Leek, JP ;
Roberts, P ;
Horgan, K ;
Markham, AF ;
Selby, PJ ;
MacLennan, KA .
JOURNAL OF PATHOLOGY, 2002, 196 (01) :59-66
[3]   The product of the t(11;18), an API2-MLT fusion, marks nearly half of gastric MALT type lymphomas without large cell proliferation [J].
Baens, M ;
Steyls, A ;
Geboes, K ;
Marynen, P ;
De Wolf-Peeters, C .
AMERICAN JOURNAL OF PATHOLOGY, 2000, 156 (04) :1433-1439
[4]   High frequency of t(11;18) in gastric mucosa-associated lymphoid tissue lymphomas in Taiwan, including one patient with high-grade transformation [J].
Chuang, SS ;
Lee, CA ;
Hamoudi, RA ;
Liu, HX ;
Lee, PS ;
Ye, HT ;
Diss, TC ;
Dogan, A ;
Isaacson, PG ;
Du, MQ .
BRITISH JOURNAL OF HAEMATOLOGY, 2003, 120 (01) :97-100
[5]   Detection of t(11;18)(q21;q21) by interphase fluorescence in situ hybridization using API2 and MLT specific probes [J].
Dierlamm, J ;
Baens, M ;
Stefanova-Ouzounova, M ;
Hinz, K ;
Wlodarska, I ;
Maes, B ;
Steyls, A ;
Driessen, A ;
Verhoef, G ;
Gaulard, P ;
Hagemeijer, A ;
Hossfeld, DK ;
De Wof-Peeters, C ;
Marynen, P .
BLOOD, 2000, 96 (06) :2215-2218
[6]   T(11-18)(Q21-Q21) IS A RECURRENT CHROMOSOME ABNORMALITY IN SMALL LYMPHOCYTIC LYMPHOMA [J].
GRIFFIN, CA ;
ZEHNBAUER, BA ;
BESCHORNER, WE ;
AMBINDER, R ;
MANN, R .
GENES CHROMOSOMES & CANCER, 1992, 4 (02) :153-157
[7]  
Hosaka S, 1999, AM J GASTROENTEROL, V94, P1951
[8]   API2-MALT1 fusion transcripts involved in mucosa-associated lymphoid tissue lymphoma -: Multiplex RT-PCR detection using formalin-fixed paraffin-embedded specimens [J].
Inagaki, H ;
Okabe, M ;
Seto, M ;
Nakamura, S ;
Ueda, R ;
Eimoto, T .
AMERICAN JOURNAL OF PATHOLOGY, 2001, 158 (02) :699-706
[9]  
Jaffe ES, 2001, CLASSIFICATION TUMOU, P157
[10]  
Kurtin PJ, 1999, AM J CLIN PATHOL, V112, P319