Membrane-associated guanylate kinases regulate adhesion and plasticity at cell junctions

被引:371
作者
Funke, L [1 ]
Dakoji, S [1 ]
Bredt, DS [1 ]
机构
[1] Univ Calif San Francisco, Dept Physiol, San Francisco, CA 94143 USA
关键词
PDZ domain; SH3; domain; synapse; tight junction; signal transduction;
D O I
10.1146/annurev.biochem.74.082803.133339
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Tissue development, differentiation, and physiology require specialized cellular adhesion and signal transduction at sites of cell-cell contact. Scaffolding proteins that tether adhesion molecules, receptors, and intracellular signaling enzymes organize macromolecular protein complexes at cellular junctions to integrate these functions. One family of such scaffolding proteins is the large group of membrane-associated guanylate kinases (MAGUKs). Genetic studies have highlighted critical roles for MAGUK proteins in the development and physiology of numerous tissues from a variety of metazoan organisms. Mutation of Drosophila discs large (dlg) disrupts epithelial septate junctions and causes overgrowth of imaginal discs. Similarly, mutation of lin-2, a related MAGUK in Caenorhabditis elegans, blocks vulval development, and mutation of the postsynaptic density protein PSD-95 impairs synaptic plasticity in mammalian brain. These diverse roles are explained by recent biochemical and structural analyses of MAGUKs, which demonstrate their capacity to assemble well-defined-yet adaptable-protein complexes at cellular junctions.
引用
收藏
页码:219 / 245
页数:27
相关论文
共 175 条
[1]   Treatment of ischemic brain damage by perturbing NMDA receptor-PSD-95 protein interactions [J].
Aarts, M ;
Liu, YT ;
Liu, LD ;
Besshoh, S ;
Arundine, M ;
Gurd, JW ;
Wang, YT ;
Salter, MW ;
Tymianski, M .
SCIENCE, 2002, 298 (5594) :846-850
[2]   Electron microscopic immunocytochemical detection of PSD-95, PSD-93, SAP-102, and SAP-97 at postsynaptic, presynaptic, and nonsynaptic sites of adult and neonatal rat visual cortex [J].
Aoki, C ;
Miko, I ;
Oviedo, H ;
Mikeladze-Dvali, T ;
Alexandre, L ;
Sweeney, N ;
Bredt, DS .
SYNAPSE, 2001, 40 (04) :239-257
[3]   The tight junction protein ZO-1 and an interacting transcription factor regulate ErbB-2 expression [J].
Balda, MS ;
Matter, K .
EMBO JOURNAL, 2000, 19 (09) :2024-2033
[4]   The ZO-1-associated Y-box factor ZONAB regulates epithelial cell proliferation and cell density [J].
Balda, MS ;
Garrett, MD ;
Matter, K .
JOURNAL OF CELL BIOLOGY, 2003, 160 (03) :423-432
[5]   Interaction of junctional adhesion molecule with the tight junction components ZO-1, cingulin, and occludin [J].
Bazzoni, G ;
Martínez-Estrada, OM ;
Orsenigo, F ;
Cordenonsi, M ;
Citi, S ;
Dejana, E .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (27) :20520-20526
[6]   Hrs-2 is an ATPase implicated in calcium-regulated secretion [J].
Bean, AJ ;
Seifert, R ;
Chen, YA ;
Sacks, R ;
Scheller, RH .
NATURE, 1997, 385 (6619) :826-829
[7]   PSD-95 regulates synaptic transmission and plasticity in rat cerebral cortex [J].
Béïque, JC ;
Andrade, R .
JOURNAL OF PHYSIOLOGY-LONDON, 2003, 546 (03) :859-867
[8]   LONG-LASTING POTENTIATION OF SYNAPTIC TRANSMISSION IN DENTATE AREA OF ANESTHETIZED RABBIT FOLLOWING STIMULATION OF PERFORANT PATH [J].
BLISS, TVP ;
LOMO, T .
JOURNAL OF PHYSIOLOGY-LONDON, 1973, 232 (02) :331-356
[9]   A SYNAPTIC MODEL OF MEMORY - LONG-TERM POTENTIATION IN THE HIPPOCAMPUS [J].
BLISS, TVP ;
COLLINGRIDGE, GL .
NATURE, 1993, 361 (6407) :31-39
[10]   Acidic motif responsible for plasma membrane association of the voltage-dependent calcium channel β1b subunit [J].
Bogdanov, Y ;
Brice, NL ;
Canti, C ;
Page, KM ;
Li, M ;
Volsen, SG ;
Dolphin, AC .
EUROPEAN JOURNAL OF NEUROSCIENCE, 2000, 12 (03) :894-902