Nucleoside, Nucleotide, and Non-Nucleoside Inhibitors of Hepatitis C Virus NS5B RNA-Dependent RNA-Polymerase

被引：247

作者：

Sofia, Michael J. ^{[1
]}

Chang, Wonsuk ^{[1
]}

Furman, Phillip A. ^{[1
]}

Mosley, Ralph T. ^{[1
]}

Ross, Bruce S. ^{[1
]}

机构：

[1] Pharmasset Inc, Princeton, NJ 08540 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2012年 / 55卷 / 06期

关键词：

STRUCTURE-BASED DESIGN; DE-NOVO INITIATION; IN-VITRO ACTIVITY; MODIFIED 2'-C-METHYL RIBONUCLEOSIDES; PHOSPHORAMIDATE PROTIDE APPROACH; ENDOPLASMIC-RETICULUM MEMBRANE; ACYL PYRROLIDINE INHIBITORS; MAJOR PHOSPHORYLATION SITE; NS3/4A PROTEASE INHIBITOR; SMALL-MOLECULE INHIBITORS;

D O I：

10.1021/jm201384j

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

[No abstract available]

引用

收藏

页码：2481 / 2531

页数：51

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