Nucleoside, Nucleotide, and Non-Nucleoside Inhibitors of Hepatitis C Virus NS5B RNA-Dependent RNA-Polymerase

被引：247

作者：

Sofia, Michael J. ^{[1
]}

Chang, Wonsuk ^{[1
]}

Furman, Phillip A. ^{[1
]}

Mosley, Ralph T. ^{[1
]}

Ross, Bruce S. ^{[1
]}

机构：

[1] Pharmasset Inc, Princeton, NJ 08540 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2012年 / 55卷 / 06期

关键词：

STRUCTURE-BASED DESIGN; DE-NOVO INITIATION; IN-VITRO ACTIVITY; MODIFIED 2'-C-METHYL RIBONUCLEOSIDES; PHOSPHORAMIDATE PROTIDE APPROACH; ENDOPLASMIC-RETICULUM MEMBRANE; ACYL PYRROLIDINE INHIBITORS; MAJOR PHOSPHORYLATION SITE; NS3/4A PROTEASE INHIBITOR; SMALL-MOLECULE INHIBITORS;

D O I：

10.1021/jm201384j

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

[No abstract available]

引用

页码：2481 / 2531

页数：51

共 413 条

[31] The NS4A Protein of Hepatitis C Virus Promotes RNA-Coupled ATP Hydrolysis by the NS3 Helicase [J].

Beran, Rudolf K. F. ;

Lindenbach, Brett D. ;

Pyle, Anna Marie .

JOURNAL OF VIROLOGY, 2009, 83 (07) :3268-3275

[32] A HIGHLY EFFICIENT ONE-FLASK METHOD FOR THE PREPARATION OF THE INDIVIDUAL DIASTEREOISOMERS OF RIBONUCLEOSIDE 3',5'-CYCLIC N-SUBSTITUTED PHOSPHORAMIDATES VIA THE DIRECT APPEL REACTION - X-RAY STRUCTURE OF TRANS-5-ISOPROPYL-2'-DEOXYURIDINE 3',5'-CYCLIC N-BENZYLPHOSPHORAMIDATE [J].

BERES, J ;

BENTRUDE, WG ;

PARKANJI, L ;

KALMAN, A ;

SOPCHIK, AE .

JOURNAL OF ORGANIC CHEMISTRY, 1985, 50 (08) :1271-1278

[33] Antiviral Activity and Mode of Action of TMC647078, a Novel Nucleoside Inhibitor of the Hepatitis C Virus NS5B Polymerase [J].

Berke, Jan Martin ;

Vijgen, Leen ;

Lachau-Durand, Sophie ;

Powdrill, Megan H. ;

Rawe, Svea ;

Sjuvarsson, Elena ;

Eriksson, Staffan ;

Goette, Matthias ;

Fransen, Els ;

Dehertogh, Pascale ;

Van den Eynde, Christel ;

Leclercq, Laurent ;

Jonckers, Tim H. M. ;

Raboisson, Pierre ;

Nilsson, Magnus ;

Samuelsson, Bertil ;

Rosenquist, Asa ;

Fanning, Gregory C. ;

Lin, Tse-I .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2011, 55 (08) :3812-3820

[34]

Bilello J.P., 2008, 59 ANN M AM ASS STUD

[35] Crystal structures of the RNA-dependent RNA polymerase genotype 2a of hepatitis C virus reveal two conformations and suggest mechanisms of inhibition by non-nucleoside inhibitors [J].

Biswal, BK ;

Cherney, MM ;

Wang, MT ;

Chan, L ;

Yannopoulos, CG ;

Bilimoria, D ;

Nicolas, O ;

Bedard, J ;

James, MNG .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (18) :18202-18210

[36] Hepatitis C virus entry depends on clathrin-mediated endocytosis [J].

Blanchard, Emmanuelle ;

Belouzard, Sandrine ;

Goueslain, Lucie ;

Wakita, Takaji ;

Dubuisson, Jean ;

Wychowski, Czeslaw ;

Rouille, Yves .

JOURNAL OF VIROLOGY, 2006, 80 (14) :6964-6972

[37] Efficient initiation of HCV RNA replication in cell culture [J].

Blight, KJ ;

Kolykhalov, AA ;

Rice, CM .

SCIENCE, 2000, 290 (5498) :1972-1974

[38] Expression of hepatitis C virus proteins inhibits interferon a signaling in the liver of transgenic mice [J].

Blindenbacher, A ;

Duong, FHT ;

Hunziker, L ;

Stutvoet, STD ;

Wang, XY ;

Terracciano, L ;

Moradpour, D ;

Blum, HE ;

Alonzi, T ;

Tripodi, M ;

La Monica, N ;

Heim, MH .

GASTROENTEROLOGY, 2003, 124 (05) :1465-1475

[39]

Brainard D.M., 2009, 44 M EUR ASS STUD LI

[40]

Brainard D.M., 2009, 60 ANN M AM ASS STUD

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