High-yielding macrocyclization conditions used in the synthesis of novel Sansalvamide A derivatives

被引：25

作者：

Styers, TJ ^{[1
]}

Rodriguez, R ^{[1
]}

Pan, PS ^{[1
]}

McAlpine, SR ^{[1
]}

机构：

[1] San Diego State Univ, Dept Chem & Biochem, San Diego, CA 92182 USA

来源：

TETRAHEDRON LETTERS | 2006年 / 47卷 / 04期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/j.tetlet.2005.11.056

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Described are the syntheses of nine Sansalvamide A derivatives using new, high-yielding, in situ deprotection-cyclization conditions that are general for this series of macrocycles, 55% average for both steps. This is 10-fold greater than previously reported yields. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：515 / 517

页数：3

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