Synthesis and cytotoxicity of novel sansalvamide A derivatives

被引：38

作者：

Carroll, CL

Johnston, JVC

Kekec, A

Brown, JD

Parry, E

Cajica, J

Medina, I

Cook, KM

Corral, R

Pan, PS

McAlpine, SR

机构：

[1] San Diego State Univ, Dept Chem, Inst Mol Biol, San Diego, CA 92182 USA

[2] San Diego State Univ, Ctr Appl & Expt Genom, San Diego, CA 92182 USA

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 16期

关键词：

D O I：

10.1021/ol051161g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Described are the syntheses of 14 derivatives of the natural product Sansalvamide A, where two are more active against HCT 116 colon cancer cell lines than the natural product. These derivatives were synthesized using a combinatorial-type strategy that permits elucidation of the amino acid role in the cytotoxicity, and they lay the groundwork for development of new anticancer agents.

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页码：3481 / 3484

页数：4

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