HCC and liver disease risks in homozygous PNPLA3 p.I148M carriers approach monogenic inheritance

被引：40

作者：

Krawczyk, Marcin ^{[1
]}

Stokes, Caroline S. ^{[1
]}

Romeo, Stefano ^{[2
]}

Lammert, Frank ^{[1
]}

机构：

[1] Univ Saarland, Med Ctr, Dept Med 2, Homburg, Germany

[2] Univ Gothenburg, Sahlgrenska Acad, Dept Mol & Clin Med, Inst Med, Gothenburg, Sweden

来源：

JOURNAL OF HEPATOLOGY | 2015年 / 62卷 / 04期

关键词：

3 GENE PNPLA3; HEPATOCELLULAR-CARCINOMA; I148M VARIANT; HEMOCHROMATOSIS; METAANALYSIS;

D O I：

10.1016/j.jhep.2014.10.048

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

引用

页码：980 / 981

页数：3

共 10 条

[1]

PNPLA3 I148M (rs738409) genetic variant is associated with hepatocellular carcinoma in obese individuals [J].

Burza, Maria Antonella ;

Pirazzi, Carlo ;

Maglio, Cristina ;

Sjoholm, Kajsa ;

Mancina, Rosellina Margherita ;

Svensson, Per-Arne ;

Jacobson, Peter ;

Adiels, Martin ;

Baroni, Marco Giorgio ;

Boren, Jan ;

Corradini, Stefano Ginanni ;

Montalcini, Tiziana ;

Sjostrom, Lars ;

Carlsson, Lena Mariana Susann ;

Romeo, Stefano .

DIGESTIVE AND LIVER DISEASE, 2012, 44 (12) :1037-1041

[2]

Systematic review with meta-analysis: the I148M variant of patatin-like phospholipase domain-containing 3 gene (PNPLA3) is significantly associated with alcoholic liver cirrhosis [J].

Chamorro, A-J. ;

Torres, J-L. ;

Miron-Canelo, J-A. ;

Gonzalez-Sarmiento, R. ;

Laso, F-J. ;

Marcos, M. .

ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2014, 40 (06) :571-581

[3]

Hemochromatosis genotypes and risk of 31 disease endpoints: Meta-analyses including 66,000 cases and 226,000 controls [J].

Ellervik, Christina ;

Birgens, Henrik ;

Tybjaerg-Hansen, Anne ;

Nordestgaard, Borge G. .

HEPATOLOGY, 2007, 46 (04) :1071-1080

[4]

A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis [J].

Feder, JN ;

Gnirke, A ;

Thomas, W ;

Tsuchihashi, Z ;

Ruddy, DA ;

Basava, A ;

Dormishian, F ;

Domingo, R ;

Ellis, MC ;

Fullan, A ;

Hinton, LM ;

Jones, NL ;

Kimmel, BE ;

Kronmal, GS ;

Lauer, P ;

Lee, VK ;

Loeb, DB ;

Mapa, FA ;

McClelland, E ;

Meyer, NC ;

Mintier, GA ;

Moeller, N ;

Moore, T ;

Morikang, E ;

Prass, CE ;

Quintana, L ;

Starnes, SM ;

Schatzman, RC ;

Brunke, KJ ;

Drayna, DT ;

Risch, NJ ;

Bacon, BR ;

Wolff, RK .

NATURE GENETICS, 1996, 13 (04) :399-408

[5]

Hepatic Iron Overload and Hepatocellular Carcinoma [J].

Kew, Michael C. .

LIVER CANCER, 2014, 3 (01) :31-40

[6]

PNPLA3-Associated Steatohepatitis: Toward a Gene-Based Classification of Fatty Liver Disease [J].

Krawczyk, Marcin ;

Portincasa, Piero ;

Lammert, Frank .

SEMINARS IN LIVER DISEASE, 2013, 33 (04) :369-379

[7]

Variant adiponutrin (PNPLA3) represents a common fibrosis risk gene: Non-invasive elastography-based study in chronic liver disease [J].

Krawczyk, Marcin ;

Gruenhage, Frank ;

Zimmer, Vincent ;

Lammert, Frank .

JOURNAL OF HEPATOLOGY, 2011, 55 (02) :299-306

[8]

Carriage of the PNPLA3 rs738409 C >G polymorphism confers an increased risk of non-alcoholic fatty liver disease associated hepatocellular carcinoma [J].

Liu, Y. -L. ;

Patman, G. L. ;

Leathart, J. B. S. ;

Piguet, A. -C. ;

Burt, A. D. ;

Dufour, J. -F. ;

Day, C. P. ;

Daly, A. K. ;

Reeves, H. L. ;

Anstee, Q. M. .

JOURNAL OF HEPATOLOGY, 2014, 61 (01) :75-81

[9]

Meta-Analysis of the Influence of I148M Variant of Patatin-Like Phospholipase Domain Containing 3 Gene (PNPLA3) on the Susceptibility and Histological Severity of Nonalcoholic Fatty Liver Disease [J].

Sookoian, Silvia ;

Pirola, Carlos J. .

HEPATOLOGY, 2011, 53 (06) :1883-1894

[10]

Genetic Variation in the PNPLA3 Gene Is Associated with Alcoholic Liver Injury in Caucasians [J].

Stickel, Felix ;

Buch, Stephan ;

Lau, Katharina ;

Schwabedissen, Henriette Meyer zu ;

Berg, Thomas ;

Ridinger, Monika ;

Rietschel, Marcella ;

Schafmayer, Clemens ;

Braun, Felix ;

Hinrichsen, Holger ;

Guenther, Rainer ;

Arlt, Alexander ;

Seeger, Marcus ;

Mueller, Sebastian ;

Seitz, Helmut Karl ;

Soyka, Michael ;

Lerch, Markus M. ;

Lammert, Frank ;

Sarrazin, Christoph ;

Kubitz, Ralf ;

Haeussinger, Dieter ;

Hellerbrand, Claus ;

Broering, Dieter ;

Schreiber, Stefan ;

Kiefer, Falk ;

Spanagel, Rainer ;

Mann, Karl ;

Datz, Christian ;

Krawczak, Michael ;

Wodarz, Norbert ;

Voelzke, Henry ;

Hampe, Jochen .

HEPATOLOGY, 2011, 53 (01) :86-95

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