Preparation of unsymmetrical biaryls via Ni- or Pd-catalyzed coupling of aryl chlorides with arylzincs

被引：64

作者：

Miller, JA ^{[1
]}

Farrell, RP ^{[1
]}

机构：

[1] Catalyt Pharmaceut, Mt View, CA 94043 USA

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 36期

关键词：

D O I：

10.1016/S0040-4039(98)01391-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Unsymmetrical biaryls may be prepared in an efficient manner using aryl chlorides as substrates in Negishi-type cross-coupling reactions with arylzinc reagents via either Ni- or Pd-catalysis. Since a wide range of functional groups (e.g., nitrile, carbonyl, ester) tolerate arylzinc compounds, this methodology allows for the direct synthesis of biaryls from aryl chlorides possessing these moieties. (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：6441 / 6444

页数：4

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