Medullary thyroid cancer: the Functions of raf-1 and human achaete-scute homologue-1

被引：35

作者：

Chen, H ^{[1
]}

Kunnimalaiyaan, M ^{[1
]}

Van Gompel, JJ ^{[1
]}

机构：

[1] Univ Wisconsin, Sch Med, Dept Surg, Ctr Comprehens Canc, Madison, WI USA

来源：

THYROID | 2005年 / 15卷 / 06期

关键词：

D O I：

10.1089/thy.2005.15.511

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Medullary thyroid cancer (MTC) is a prototypic neuroendocrine tumor of the thyroid C cells. Other than surgery, there are no curative therapies for MTC. In this review, we detail recent studies that suggest that targeting specific signaling pathways may be a viable strategy to control MTC tumor progression. Specifically, we discuss the role of the raf-1 and achaete-scute homologue-1 pathways in the MTC tumor growth and differentiation.

引用

页码：511 / 521

页数：11

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