Achaete-scute homolog-1 and development Notch in lung neuroendocrine and cancer

被引：98

作者：

Ball, DW ^{[1
]}

机构：

[1] Johns Hopkins Med Inst, Sidney Kimmel Comprehens Canc Ctr, Dept Med, Baltimore, MD 21231 USA

来源：

CANCER LETTERS | 2004年 / 204卷 / 02期

关键词：

hASH1; mammalian achaete-scute homolog-1; Notch; hairy-enhancer of split 1; neuroendocrine; lung development; lung cancer;

D O I：

10.1016/S0304-3835(03)00452-X

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Achaete-scute homolog-1 (termed Mash1 in rodents, hASH1 in humans) is a basic helix-loop-helix transcription factor important in early development of neural and neuroendocrine (NE) progenitor cells in multiple tissues including the CNS, autonomic nervous system, adrenal medulla, thyroid, lung, and prostate, among others. This review discusses how progress in developmental neurobiology of Mash1 has translated into novel insights in NE tumor biology, particularly for small cell lung cancer. Inhibition of this factor by the Notch pathway is essential in regulating NE commitment in airway epithelial precursor cells. and may play a comparable role in modulating phenotypes of lung cancer and other tumors. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

引用

页码：159 / 169

页数：11

共 69 条

[1]

[Anonymous], 2002, Genome Biol

[2] Notch signalling controls pancreatic cell differentiation [J].

Apelqvist, Å ;

Li, H ;

Sommer, L ;

Beatus, P ;

Anderson, DJ ;

Honjo, T ;

de Angelis, MH ;

Lendahl, U ;

Edlund, H .

NATURE, 1999, 400 (6747) :877-881

[3]

Bellusci S, 1997, DEVELOPMENT, V124, P53

[4] Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses [J].

Bhattacharjee, A ;

Richards, WG ;

Staunton, J ;

Li, C ;

Monti, S ;

Vasa, P ;

Ladd, C ;

Beheshti, J ;

Bueno, R ;

Gillette, M ;

Loda, M ;

Weber, G ;

Mark, EJ ;

Lander, ES ;

Wong, W ;

Johnson, BE ;

Golub, TR ;

Sugarbaker, DJ ;

Meyerson, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (24) :13790-13795

[5] THE LUNG-SPECIFIC SURFACTANT PROTEIN-B GENE PROMOTER IS A TARGET FOR THYROID TRANSCRIPTION FACTOR-1 AND HEPATOCYTE NUCLEAR FACTOR-3, INDICATING COMMON FACTORS FOR ORGAN-SPECIFIC GENE-EXPRESSION ALONG THE FOREGUT AXIS [J].

BOHINSKI, RJ ;

DILAURO, R ;

WHITSETT, JA .

MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (09) :5671-5681

[6] Relationship between neuroendocrine features and prognostic parameters in human prostate adenocarcinoma [J].

Bollito, E ;

Berruti, A ;

Bellina, A ;

Mosca, A ;

Leonardo, E ;

Tarabuzzi, R ;

Cappia, S ;

Mari, M ;

Tampellini, M ;

Fontana, D ;

Gubetta, L ;

Angeli, A ;

Dogliotti, L .

ANNALS OF ONCOLOGY, 2001, 12 :S159-S164

[7] An achaete-scute homologue essential for neuroendocrine differentiation in the lung [J].

Borges, M ;

Linnoila, RI ;

vandeVelde, HJK ;

Chen, H ;

Nelkin, BD ;

Mabry, M ;

Baylin, SB ;

Ball, DW .

NATURE, 1997, 386 (6627) :852-855

[8]

Cagle PT, 1997, AM J PATHOL, V150, P393

[9] How to pattern an epithelium:: lessons from achaete-scute regulation on the notum of Drosophila [J].

Calleja, M ;

Renaud, O ;

Usui, K ;

Pistillo, D ;

Morata, G ;

Simpson, P .

GENE, 2002, 292 (1-2) :1-12

[10] Molecular regulation of lung development [J].

Cardoso, WV .

ANNUAL REVIEW OF PHYSIOLOGY, 2001, 63 :471-494

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