Effect of acute and chronic tea consumption on platelet aggregation in patients with coronary artery disease

被引:72
作者
Duffy, SJ
Vita, JA
Holbrook, M
Swerdloff, PL
Keaney, JF
机构
[1] Boston Univ, Sch Med, Whitaker Cardiovasc Inst, Boston, MA 02118 USA
[2] Boston Univ, Sch Med, Evans Dept Med, Boston, MA 02118 USA
关键词
platelet aggregation; tea; flavonoids; coronary artery disease;
D O I
10.1161/01.ATV.21.6.1084
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Epidemiological studies suggest that tea consumption is associated with a decreased risk of cardiovascular events, but the mechanisms of benefit remain undefined. Platelet aggregation is a precipitating event in cardiovascular disease, and tea contains antioxidant flavonoids that are known to decrease platelet aggregation in vitro. To test the effect of tea consumption on platelet aggregation, we randomized 49 patients with coronary artery disease to either 450 mt of black tea or water consumed initially, followed by 900 mt of tea or water daily for 4 weeks in a crossover design. Ex vivo platelet aggregation in platelet-rich plasma was assessed in response to ADP and thrombin receptor-activating peptide at baseline and 2 hours and 4 weeks after beverage consumption. We observed dose-dependent platelet aggregation in response to each agonist, and neither relation was altered by acute or chronic tea consumption. Plasma flavonoids increased with acute and chronic tea consumption, indicating adequate absorption of tea flavonoids. In conclusion. these results demonstrate that acute and chronic black tea consumption does not affect ex vivo platelet aggregation in patients with coronary artery disease. These findings suggest that an effect of tea flavonoids on platelet aggregation is unlikely to be the explanation for the reduction in risk of cardiovascular events noted in epidemiological studies.
引用
收藏
页码:1084 / 1089
页数:6
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