The myotubularin family of lipid phosphatases

被引：73

作者：

Clague, MJ ^{[1
]}

Lorenzo, O ^{[1
]}

机构：

[1] Univ Liverpool, Physiol Lab, Liverpool L69 3BX, Merseyside, England

来源：

TRAFFIC | 2005年 / 6卷 / 12期

基金：

英国惠康基金;

关键词：

endocytosis; lipid phosphatase; myotubularin; phosphoinositides;

D O I：

10.1111/j.1600-0854.2005.00338.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The myotubularins (MTMs) constitute a large family of phosphoinositide lipid 3-phosphatases with specificity for PtdIns3P and PtdIns (3,5)P-2. Mutations in MTM proteins are associated with inherited conditions such as myotubular myopathy and Charcot-Marie-Tooth syndrome. The substrate lipids are known to be regulators of the endosomal pathway through recruitment of specific effector proteins. Hydrolysis of PtdIns (3,5)P-2 provides a biosynthetic pathway to the production of PtdIns5P, which itself can allosterically activate MTMs. We review the properties of this intriguing family of proteins and discuss potential physiological functions that include regulation of the endocytic pathway.

引用

页码：1063 / 1069

页数：7

共 52 条

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