I-proteins - a proposed switch in myotubularin function

被引：8

作者：

Clague, MJ

Dove, SK

Barr, FA

机构：

[1] Univ Liverpool, Physiol Lab, Liverpool L69 3BX, Merseyside, England

[2] Univ Birmingham, Sch Biosci, Birmingham B15 2TT, W Midlands, England

[3] Max Planck Inst Biochem, Dept Cell Biol, D-82152 Martinsried, Germany

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2004年 / 29卷 / 02期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/j.tibs.2003.12.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this article, we consider the functions of the myotubularins - a large family of phosphoinositide 3-phosphatases. By analogy with the phosphatidylinositol 3-phosphatase PTEN (phosphatase and tensin homolog deleted in chromosome ten) and many protein phosphatases, it has been proposed that the primary function of this protein family is to regulate substrate levels, in this case phosphatidylinositol (3)-phosphate. We propose an alternate, or additional, function that is analogous to the G-protein family of phosphatases, which use nucleotide-dependent conformational changes to transduce signals or do mechanical work.

引用

收藏

页码：58 / 61

页数：4

相关论文

共 33 条

[1] PDGF-DEPENDENT TYROSINE PHOSPHORYLATION STIMULATES PRODUCTION OF NOVEL POLYPHOSPHOINOSITIDES IN INTACT-CELLS [J].

AUGER, KR ;

SERUNIAN, LA ;

SOLTOFF, SP ;

LIBBY, P ;

CANTLEY, LC .

CELL, 1989, 57 (01) :167-175

[2] Mutations in MTMR13, a new pseudophosphatase homologue of MTMR2 and Sbf1, in two families with an autosomal recessive demyelinating form of Charcot-Marie-Tooth disease associated with early-onset glaucoma [J].

Azzedine, H ;

Bolino, A ;

Taïeb, T ;

Birouk, N ;

Di Duca, M ;

Bouhouche, A ;

Benamou, S ;

Mrabet, A ;

Hammadouche, T ;

Chkili, T ;

Gouider, R ;

Ravazzolo, R ;

Brice, A ;

Laporte, J ;

LeGuern, E .

AMERICAN JOURNAL OF HUMAN GENETICS, 2003, 72 (05) :1141-1153

[3] Membrane association of myotubularin-related protein 2 is mediated by a pleckstrin homology-GRAM domain and a coiled-coil dimerization module [J].

Berger, P ;

Schaffitzel, C ;

Berger, I ;

Ban, N ;

Suter, U .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (21) :12177-12182

[4] Myotubularin, a phosphatase deficient in myotubular myopathy, acts on phosphatidylinositol 3-kinase and phosphatidylinositol 3-phosphate pathway [J].

Blondeau, F ;

Laporte, J ;

Bodin, S ;

Superti-Furga, G ;

Payrastre, B ;

Mandel, JL .

HUMAN MOLECULAR GENETICS, 2000, 9 (15) :2223-2229

[5] Charcot-Marie-Tooth type 4B is caused by mutations in the gene encoding myotubularin-related protein-2 [J].

Bolino, A ;

Muglia, M ;

Conforti, FL ;

LeGuern, E ;

Salih, MAM ;

Georgiou, DM ;

Christodoulou, K ;

Hausmanowa-Petrusewicz, I ;

Mandich, P ;

Schenone, A ;

Gambardella, A ;

Bono, F ;

Quattrone, A ;

Devoto, M ;

Monaco, AP .

NATURE GENETICS, 2000, 25 (01) :17-19

[6] The lipid phosphatase myotubularin is essential for skeletal muscle maintenance but not for myogenesis in mice [J].

Buj-Bello, A ;

Laugel, V ;

Messaddeq, N ;

Zahreddine, H ;

Laporte, J ;

Pellissiert, JF ;

Mandel, JL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (23) :15060-15065

[7] The phosphoinositide 3-kinase pathway [J].

Cantley, LC .

SCIENCE, 2002, 296 (5573) :1655-1657

[8] Inositol lipids are regulated during cell cycle progression in the nuclei of murine erythroleukaemia cells [J].

Clarke, JH ;

Letcher, AJ ;

D'Santos, CS ;

Halstead, JR ;

Irvine, RF ;

Divecha, N .

BIOCHEMICAL JOURNAL, 2001, 357 (03) :905-910

[9] Phosphatidylinositol 3,5-bisphosphate: metabolism and function [J].

Cooke, FT .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2002, 407 (02) :143-151

[10] Modular phosphoinositide-binding domains - their role in signalling and membrane trafficking [J].

Cullen, PJ ;

Cozier, GE ;

Banting, G ;

Mellor, H .

CURRENT BIOLOGY, 2001, 11 (21) :R882-R893

← 1 2 3 4 →