The problem of transplanting the sensitized patient: Whose problem is it?

被引:27
作者
Jackson, Annette M. [1 ]
Zachary, Andrea A. [1 ]
机构
[1] Johns Hopkins Univ, Sch Med, Immunogenet Lab, Baltimore, MD 21205 USA
来源
FRONTIERS IN BIOSCIENCE-LANDMARK | 2008年 / 13卷
关键词
transplantation; HLA; PRA; sensitization; alloantibodies; rejection; review;
D O I
10.2741/2770
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Transplantation is the treatment of choice for end-stage renal failure and a life-saving treatment for failure of other major organs. Improvements in surgical techniques, histocompatibility testing, and immunosuppressive drugs have significantly improved both patient and graft survival (1-4). However, there are formidable barriers to the successful transplantation of patients who possess HLA-specific antibodies. Sensitized patients wait longer for a transplant and, once transplanted, experience more rejection episodes and have decreased graft survival compared to non-sensitized recipients (5-8). Improvements in HLA-specific antibody detection have expanded the donor pool available to sensitized patients (914) and desensitization protocols designed to reduce the breadth and amount of HLA-specific antibody have found increased success during the last decade (15-20). Determining the appropriate course of treatment for the sensitized patient requires accurate immunologic characterization and clinical assessment of the patient. Together, the transplant physician and histocompatibility expert must determine what constitutes a compatible donor and assess the patient's risk for a particular transplant. Thus, sensitization to HLA antigens is a problem for the patient, the transplant physician, and the histocompatibility laboratory.
引用
收藏
页码:1396 / 1412
页数:17
相关论文
共 174 条
[91]   Allosensitization in heart transplantation: implications and management strategies [J].
Mehra, MR ;
Uber, PA ;
Uber, WE ;
Scott, RL ;
Park, MH .
CURRENT OPINION IN CARDIOLOGY, 2003, 18 (02) :153-158
[92]   Humoral rejection of human organ transplants [J].
Michaels, PJ ;
Fishbein, MC ;
Colvin, RB .
SPRINGER SEMINARS IN IMMUNOPATHOLOGY, 2003, 25 (02) :119-140
[93]   Humoral rejection in cardiac transplantation: Risk factors, hemodynamic consequences and relationship to transplant coronary artery disease [J].
Michaels, PJ ;
Espejo, ML ;
Kobashigawa, J ;
Alejos, JC ;
Burch, C ;
Takemoto, S ;
Reed, EF ;
Fishbein, MC .
JOURNAL OF HEART AND LUNG TRANSPLANTATION, 2003, 22 (01) :58-69
[94]   Clinical relevance of anti-HLA antibodies detected by flow-cytometry bead-based assays - Single-center experience [J].
Mihaylova, Anastassia ;
Baltadjieva, Daniela ;
Boneva, Petia ;
Ivanova, Milena ;
Penkova, Kalina ;
Marinova, Daniela ;
Mihailova, Snejina ;
Paskalev, Emil ;
Simeonov, Petar ;
Naumova, Elissaveta .
HUMAN IMMUNOLOGY, 2006, 67 (10) :787-794
[95]   Association of kidney transplant failure and antibodies against MICA [J].
Mizutani, Kazuo ;
Terasaki, Paul ;
Bignon, Jean Denis ;
Hourmant, Maryvonne ;
Cesbron-Gautier, Anne ;
Shih, Remi N. J. ;
Pei, Rui ;
Lee, Jarhow ;
Ozawa, Miyuki .
HUMAN IMMUNOLOGY, 2006, 67 (09) :683-691
[96]   A significant role for histocompatibility in human islet transplantation [J].
Mohanakumar, T. ;
Narayanan, Kishore ;
Desai, Niraj ;
Ramachandran, Sabarinathan ;
Shenoy, Surendra ;
Jendrisak, Martin ;
Susskind, Brian M. ;
Olack, Barbara ;
Benshoff, Nicholas ;
Phelan, Donna L. ;
Brennan, Daniel C. ;
Fernandez, Luis A. ;
Odorico, Jon S. ;
Polonsky, Kenneth S. .
TRANSPLANTATION, 2006, 82 (02) :180-187
[97]   RENAL-ALLOGRAFT REJECTION ASSOCIATED WITH PRESENSITIZATION TO HLA-DR ANTIGENS [J].
MOHANAKUMAR, T ;
RHODES, C ;
MENDEZPICON, G ;
GOLDMAN, M ;
MONCURE, C ;
LEE, H .
TRANSPLANTATION, 1981, 31 (01) :93-95
[98]   Clinical results from transplanting incompatible live kidney donor/recipient pairs using kidney paired donation [J].
Montgomery, RA ;
Zachary, AA ;
Ratner, LE ;
Segev, DL ;
Hiller, JM ;
Houp, J ;
Cooper, M ;
Kavoussi, L ;
Jarrett, T ;
Burdick, J ;
Maley, WR ;
Melancon, JK ;
Kozlowski, T ;
Simpkins, CE ;
Phillips, M ;
Desai, A ;
Collins, V ;
Reeb, B ;
Kraus, E ;
Rabb, H ;
Leffell, MS ;
Warren, DS .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2005, 294 (13) :1655-1663
[99]   Transplanting patients with a positive donor-specific crossmatch: A single center's perspective [J].
Montgomery, RA ;
Zachary, AA .
PEDIATRIC TRANSPLANTATION, 2004, 8 (06) :535-542
[100]   Plasmapheresis and intravenous immune globulin provides effective rescue therapy for refractory humoral rejection and allows kidneys to be successfully transplanted into cross-match-positive recipients [J].
Montgomery, RA ;
Zachary, AA ;
Racusen, LC ;
Leffell, MS ;
King, KE ;
Burdick, J ;
Maley, WR ;
Ratner, LE .
TRANSPLANTATION, 2000, 70 (06) :887-895