Simultaneous analysis of 16 sulfonamide and trimethoprim antibiotics in environmental waters by liquid chromatography-electrospray tandem mass spectrometry

被引：97

作者：

Chang, Hong ^{[1
]}

Hu, Jianying ^{[1
]}

Asami, Mari ^{[2
]}

Kunikane, Shoichi ^{[2
]}

机构：

[1] Peking Univ, Coll Urban & Environm Sci, Beijing 100871, Peoples R China

[2] Natl Inst Publ Hlth, Dept Water Supply Engn, Wako, Saitama 3510197, Japan

来源：

JOURNAL OF CHROMATOGRAPHY A | 2008年 / 1190卷 / 1-2期

基金：

中国国家自然科学基金;

关键词：

environmental analysis; silica cartridge cleanup; sulfonamides; LC-ESI-MS/MS;

D O I：

10.1016/j.chroma.2008.03.057

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A sensitive liquid chromatography-electrospray tandem mass spectrometry method combined with solid-phase extraction and silica cartridge cleanup was established for 16 sulfonamides and trimethoprim in various water matrices. Signal suppression of all target analytes in sewage treatment plant influent, effluent and river water was improved by this method developed in this study. The method detection limits for 17 analytes were 20-200 pg/L for influent, 16-120 pg/L for effluent and 8.0-60 pg/L for river water with overall mean recoveries of 62-102% in all studied matrices. This method was used to analyze residual sulfonamides and trimethoprim, in wastewater and river samples from Japan, and 8 analytes (0.08 (sulfadimethoxine)-161 ng/L (sulfapyridine) in wastewater and 10 (0.03 (sulfamethizol)-8.9 ng/L (sulfaquinoxaline) in river samples were detected. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：390 / 393

页数：4

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