Bone marrow angiogenesis and mast cell density increase simultaneously with progression of human multiple myeloma

被引：207

作者：

Ribatti, D

Vacca, A

Nico, B

Quondamatteo, F

Ria, R

Minischetti, M

Marzullo, A

Herken, R

Roncali, L

Dammacco, F

机构：

[1] Univ Bari, Sch Med, Inst Human Anat Histol & Embryol, I-70124 Bari, Italy

[2] Univ Bari, Sch Med, Dept Biomed Sci & Human Oncol, I-70124 Bari, Italy

[3] Univ Gottingen, Zentrum Anat Abt Histol, D-37075 Gottingen, Germany

[4] Univ Bari, Sch Med, Inst Pathol, I-70124 Bari, Italy

来源：

BRITISH JOURNAL OF CANCER | 1999年 / 79卷 / 3-4期

关键词：

angiogenesis; mast cell; multiple myeloma; tumour progression;

D O I：

10.1038/sj.bjc.6690070

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Immunohistochemical, cytochemical and ultrastructural data showing vivid angiogenesis and numerous mast cells (MCs) in the bone marrow of 24 patients with active multiple myeloma (MM) compared with 34 patients with non-active MM and 22 patients with monoclonal gammopathy of undetermined significance (MGUS) led us to hypothesize that angiogenesis parallels progression of MM, and that MCs participate in its induction via angiogenic factors in their secretory granules.

引用

页码：451 / 455

页数：5

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