Rapid microscale synthesis, a new method for lead optimization using robotics and solution phase chemistry: Application to the synthesis and optimization of corticotropin-releasing factor(1) receptor antagonists

被引:66
作者
Whitten, JP
Xie, YF
Erickson, PE
Webb, TR
DeSouza, EB
Grigoriadis, DE
McCarthy, JR
机构
[1] Neurocrine Biosciences, San Diego, CA 92121
关键词
D O I
10.1021/jm960148m
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
[No abstract available]
引用
收藏
页码:4354 / 4357
页数:4
相关论文
共 44 条
[1]  
Aldrich P. E, 1995, PCT Int. Appl., Patent No. 9510506
[2]   CARBON-CARBON BOND-FORMING METHODS ON SOLID SUPPORT - UTILIZATION OF KENNER SAFETY-CATCH LINKER [J].
BACKES, BJ ;
ELLMAN, JA .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (24) :11171-11172
[3]   AN EXPEDIENT AND HIGH-YIELDING METHOD FOR THE SOLID-PHASE SYNTHESIS OF DIVERSE 1,4-BENZODIAZEPINE-2,5-DIONES [J].
BOOJAMRA, CG ;
BUROW, KM ;
ELLMAN, JA .
JOURNAL OF ORGANIC CHEMISTRY, 1995, 60 (18) :5742-5743
[4]  
Bright G. M, 1994, PCT Int. Appl., Patent No. 9413661
[5]  
Bright G. M, 1994, PCT Int. Appl., Patent No. 9413644
[6]   THE COMBINATORIAL SYNTHESIS AND CHEMICAL AND BIOLOGICAL EVALUATION OF A 1,4-BENZODIAZEPINE LIBRARY [J].
BUNIN, BA ;
PLUNKETT, MJ ;
ELLMAN, JA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (11) :4708-4712
[7]   A GENERAL AND EXPEDIENT METHOD FOR THE SOLID-PHASE SYNTHESIS OF 1,4-BENZODIAZEPINE DERIVATIVES [J].
BUNIN, BA ;
ELLMAN, JA .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1992, 114 (27) :10997-10998
[8]  
CHALMERS DT, 1995, J NEUROSCI, V15, P6340
[9]   IDENTIFICATION OF A 7 TRANSMEMBRANE HELIX RECEPTOR FOR CORTICOTROPIN-RELEASING FACTOR AND SAUVAGINE IN MAMMALIAN BRAIN [J].
CHANG, CP ;
PEARSE, RV ;
OCONNELL, S ;
ROSENFELD, MG .
NEURON, 1993, 11 (06) :1187-1195
[10]  
Chen C, 1996, J MED CHEM, V39, P4358