Fluorescent Nanorods and Nanospheres for Real-Time In Vivo Probing of Nanoparticle Shape-Dependent Tumor Penetration

被引：412

作者：

Chauhan, Vikash P. ^{[2
,3
,4
]}

Popovic, Zoran ^{[1
]}

Chen, Ou ^{[1
]}

Cui, Jian ^{[1
]}

Fukumura, Dai ^{[2
,3
]}

Bawendi, Moungi G. ^{[1
]}

Jain, Rakesh K. ^{[2
,3
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

[2] Harvard Univ, Sch Med, Boston, MA 02114 USA

[3] Massachusetts Gen Hosp, Dept Radiat Oncol, Edwin L Steele Lab, Boston, MA 02114 USA

[4] Harvard Univ, Harvard Sch Engn & Appl Sci, Cambridge, MA 02138 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 48期

关键词：

cancer; imaging agents; luminescence; microscopy; nanoparticles; EXTRACELLULAR-MATRIX; SEEDED GROWTH; DIFFUSION; LIPOSOMES; TRANSPORT; PARTICLES; XENOGRAFT; DELIVERY; IMPROVES; MICROENVIRONMENT;

D O I：

10.1002/anie.201104449

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Shape dependent: Fluorescent quantum-dot-based nanospheres and nanorods with identical hydrodynamic size and surface properties but different aspect ratios were developed for real-time in vivo tumor imaging. The nanorods exhibited superior transport and distribution into mammary tumors in vivo versus nanospheres of similar plasma half-life. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

收藏

页码：11417 / 11420

页数：4

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