Sequence-specific synthesis of macromolecules using DNA-templated chemistry

被引：58

作者：

Milnes, Phillip J. ^{[2
]}

McKee, Mireya L. ^{[1
]}

Bath, Jonathan ^{[1
]}

Song, Lijiang ^{[2
]}

Stulz, Eugen ^{[3
]}

Turberfield, Andrew J. ^{[1
]}

O'Reilly, Rachel K. ^{[2
]}

机构：

[1] Univ Oxford, Dept Phys, Clarendon Lab, Oxford OX1 3PU, England

[2] Univ Warwick, Dept Chem, Coventry CV4 7AL, W Midlands, England

[3] Univ Southampton, Sch Chem, Southampton SO17 1BJ, Hants, England

来源：

CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 45期

基金：

英国工程与自然科学研究理事会;

关键词：

MULTISTEP ORGANIC-SYNTHESIS; SOLID-PHASE; TRANSLATION; DISCOVERY; POLYMERIZATION; SELECTION; LIBRARY; SYSTEM;

D O I：

10.1039/c2cc31975f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Using a strand exchange mechanism we have prepared, by DNA templated chemistry, two 10-mers with defined and tunable monomer sequences. An optimized reaction protocol achieves 85% coupling yield per step, demonstrating that DNA-templated chemistry is a powerful tool for the synthesis of macromolecules with full sequence control.

引用

页码：5614 / 5616

页数：3

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