Cellular genomics for complex traits

被引：28

作者：

Dermitzakis, Emmanouil T. ^{[1
,2
]}

机构：

[1] Univ Geneva, Sch Med, Dept Genet Med & Dev, CH-1211 Geneva, Switzerland

[2] Inst Genet & Genom Geneva iGE3, Geneva, Switzerland

来源：

NATURE REVIEWS GENETICS | 2012年 / 13卷 / 03期

基金：

瑞士国家科学基金会;

关键词：

GENE-EXPRESSION VARIATION; MUTATIONS; CHROMATIN;

D O I：

10.1038/nrg3115

中图分类号：

Q3 [遗传学];

学科分类号：

071007 [遗传学];

摘要：

Recent developments in the collection and analysis of cellular multilayered data in large cohorts with extensive organismal phenotyping promise to reveal links between genetic variation and biological processes. The use of these cellular resources as models for human biology - known as 'cellular phenotyping' - is likely to transform our understanding of the genetic and long-term environmental influences on complex traits. I discuss the advantages and caveats of a deeper analysis of cellular phenotypes in large cohorts and assess the methodological advances, resource needs and prospects of this new approach.

引用

页码：215 / 220

页数：6

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