From gene expression to disease risk

被引：57

作者：

Dermitzakis, Emmanouil T. ^{[1
]}

机构：

[1] Wellcome Trust Sanger Inst, Cambridge CB10 1SA, England

来源：

NATURE GENETICS | 2008年 / 40卷 / 05期

关键词：

D O I：

10.1038/ng0508-492

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Gene expression can be an indicator of cellular state, and studies characterizing variation in gene expression have been useful on the cellular level. Two new studies now provide the first direct demonstration of the successful use of the multidimensionality of gene expression to dissect the genetic architecture of complex diseases.

引用

页码：492 / 493

页数：3

共 11 条

[1] The knockout mouse project [J].

Austin, CP ;

Battey, JF ;

Bradley, A ;

Bucan, M ;

Capecchi, M ;

Collins, FS ;

Dove, WF ;

Duyk, G ;

Dymecki, S ;

Eppig, JT ;

Grieder, FB ;

Heintz, N ;

Hicks, G ;

Insel, TR ;

Joyner, A ;

Koller, BH ;

Lloyd, KCK ;

Magnuson, T ;

Moore, MW ;

Nagy, A ;

Pollock, JD ;

Roses, AD ;

Sands, AT ;

Seed, B ;

Skarnes, WC ;

Snoddy, J ;

Soriano, P ;

Stewart, DJ ;

Stewart, F ;

Stillman, B ;

Varmus, H ;

Varticovski, L ;

Verma, IM ;

Vogt, TF ;

von Melchner, H ;

Witkowski, J ;

Woychik, RP ;

Wurst, W ;

Yancopoulos, GD ;

Young, SG ;

Zambrowicz, B .

NATURE GENETICS, 2004, 36 (09) :921-924

[2] Variations in DNA elucidate molecular networks that cause disease [J].

Chen, Yanqing ;

Zhu, Jun ;

Lum, Pek Yee ;

Yang, Xia ;

Pinto, Shirly ;

MacNeil, Douglas J. ;

Zhang, Chunsheng ;

Lamb, John ;

Edwards, Stephen ;

Sieberts, Solveig K. ;

Leonardson, Amy ;

Castellini, Lawrence W. ;

Wang, Susanna ;

Champy, Marie-France ;

Zhang, Bin ;

Emilsson, Valur ;

Doss, Sudheer ;

Ghazalpour, Anatole ;

Horvath, Steve ;

Drake, Thomas A. ;

Lusis, Aldons J. ;

Schadt, Eric E. .

NATURE, 2008, 452 (7186) :429-435

[3] Multiple rare Alleles contribute to low plasma levels of HDL cholesterol [J].

Cohen, JC ;

Kiss, RS ;

Pertsemlidis, A ;

Marcel, YL ;

McPherson, R ;

Hobbs, HH .

SCIENCE, 2004, 305 (5685) :869-872

[4] A genome-wide association study of global gene expression [J].

Dixon, Anna L. ;

Liang, Liming ;

Moffatt, Miriam F. ;

Chen, Wei ;

Heath, Simon ;

Wong, Kenny C. C. ;

Taylor, Jenny ;

Burnett, Edward ;

Gut, Ivo ;

Farrall, Martin ;

Lathrop, G. Mark ;

Abecasis, Goncalo R. ;

Cookson, William O. C. .

NATURE GENETICS, 2007, 39 (10) :1202-1207

[5] Genetics of gene expression and its effect on disease [J].

Emilsson, Valur ;

Thorleifsson, Gudmar ;

Zhang, Bin ;

Leonardson, Amy S. ;

Zink, Florian ;

Zhu, Jun ;

Carlson, Sonia ;

Helgason, Agnar ;

Walters, G. Bragi ;

Gunnarsdottir, Steinunn ;

Mouy, Magali ;

Steinthorsdottir, Valgerdur ;

Eiriksdottir, Gudrun H. ;

Bjornsdottir, Gyda ;

Reynisdottir, Inga ;

Gudbjartsson, Daniel ;

Helgadottir, Anna ;

Jonasdottir, Aslaug ;

Jonasdottir, Adalbjorg ;

Styrkarsdottir, Unnur ;

Gretarsdottir, Solveig ;

Magnusson, Kristinn P. ;

Stefansson, Hreinn ;

Fossdal, Ragnheidur ;

Kristjansson, Kristleifur ;

Gislason, Hjortur G. ;

Stefansson, Tryggvi ;

Leifsson, Bjorn G. ;

Thorsteinsdottir, Unnur ;

Lamb, John R. ;

Gulcher, Jeffrey R. ;

Reitman, Marc L. ;

Kong, Augustine ;

Schadt, Eric E. ;

Stefansson, Kari .

NATURE, 2008, 452 (7186) :423-U2

[6] Discovery of expression QTLs using large-scale transcriptional profiling in human lymphocytes [J].

Goering, Harald H. H. ;

Curran, Joanne E. ;

Johnson, Matthew P. ;

Dyer, Thomas D. ;

Charlesworth, Jac ;

Cole, Shelley A. ;

Jowett, Jeremy B. M. ;

Abraham, Lawrence J. ;

Rainwater, David L. ;

Comuzzie, Anthony G. ;

Mahaney, Michael C. ;

Almasy, Laura ;

MacCluer, Jean W. ;

Kissebah, Ahmed H. ;

Collier, Gregory R. ;

Moses, Eric K. ;

Blangero, John .

NATURE GENETICS, 2007, 39 (10) :1208-1216

[7] Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma [J].

Moffatt, Miriam F. ;

Kabesch, Michael ;

Liang, Liming ;

Dixon, Anna L. ;

Strachan, David ;

Heath, Simon ;

Depner, Martin ;

von Berg, Andrea ;

Bufe, Albrecht ;

Rietschel, Ernst ;

Heinzmann, Andrea ;

Simma, Burkard ;

Frischer, Thomas ;

Willis-Owen, Saffron A. G. ;

Wong, Kenny C. C. ;

Illig, Thomas ;

Vogelberg, Christian ;

Weiland, Stephan K. ;

von Mutius, Erika ;

Abecasis, Goncalo R. ;

Farrall, Martin ;

Gut, Ivo G. ;

Lathrop, G. Mark ;

Cookson, William O. C. .

NATURE, 2007, 448 (7152) :470-U5

[8] Genetic inheritance of gene expression in human cell lines [J].

Monks, SA ;

Leonardson, A ;

Zhu, H ;

Cundiff, P ;

Pietrusiak, P ;

Edwards, S ;

Phillips, JW ;

Sachs, A ;

Schadt, EE .

AMERICAN JOURNAL OF HUMAN GENETICS, 2004, 75 (06) :1094-1105

[9] Genetic analysis of genome-wide variation in human gene expression [J].

Morley, M ;

Molony, CM ;

Weber, TM ;

Devlin, JL ;

Ewens, KG ;

Spielman, RS ;

Cheung, VG .

NATURE, 2004, 430 (7001) :743-747

[10] Population genomics of human gene expression [J].

Stranger, Barbara E. ;

Nica, Alexandra C. ;

Forrest, Matthew S. ;

Dimas, Antigone ;

Bird, Christine P. ;

Beazley, Claude ;

Ingle, Catherine E. ;

Dunning, Mark ;

Flicek, Paul ;

Koller, Daphne ;

Montgomery, Stephen ;

Tavare, Simon ;

Deloukas, Panos ;

Dermitzakis, Emmanouil T. .

NATURE GENETICS, 2007, 39 (10) :1217-1224

← 1 2 →