Highly enantioselective catalytic fluorination and chlorination reactions of carbonyl compounds capable of two-point binding

被引：294

作者：

Shibata, N ^{[1
]}

Kohno, J

Takai, K

Ishimaru, T

Nakamura, S

Toru, T

Kanemasa, S

机构：

[1] Nagoya Inst Technol, Grad Sch Engn, Dept Appl Chem, Showa Ku, Nagoya, Aichi 4668555, Japan

[2] Kyushu Univ, Inst Mat Chem & Engn, Kasuga 8168580, Japan

[3] Nagoya Inst Technol, Grad Sch Engn, Dept Appl Chem, Showa Ku, Nagoya, Aichi 4668555, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 27期

关键词：

asymmetric amplification; asymmetric synthesis; enantioselectivity; fluorination; halogenation;

D O I：

10.1002/anie.200501041

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) New tools in drug development: The catalytic enantioselective fluorination and chlorination reactions of carbonyl compounds containing an additional binding site (see scheme) proceed with extremely high enantioselectivity and require low catalyst loadings (2-10 mol% dbfox-Ph/ NiII). Asymmetric amplification is also observed in these enantioselective halogenations. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：4204 / 4207

页数：4

共 51 条

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