The functional consequences of alternative promoter use in mammalian genomes

被引：289

作者：

Davuluri, Ramana V. ^{[2
]}

Suzuki, Yutaka ^{[1
]}

Sugano, Sumio ^{[1
]}

Plass, Christoph ^{[2
]}

Huang, Tim H. -M. ^{[2
]}

机构：

[1] Univ Tokyo, Dept Med Genome Sci, Grad Sch Frontier Sci, Chiba 2778562, Japan

[2] Ohio State Univ, Ctr Comprehens Canc, Human Canc Genet Program, Dept Mol Virol Immunol & Med Genet, Columbus, OH 43210 USA

来源：

TRENDS IN GENETICS | 2008年 / 24卷 / 04期

关键词：

D O I：

10.1016/j.tig.2008.01.008

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We are beginning to appreciate the increasing complexity of mammalian gene structure. A phenomenon that adds an important dimension to this complexity is the use of alternative gene promoters that drive widespread cell type, tissue type or developmental gene regulation. Recent annotations of the human genome suggest that almost one half of the protein-coding genes contain alternative promoters, including those of many disease-associated genes. Aberrant use of one promoter over another has been found to be associated with various diseases, including cancer. Here we discuss the functional consequences of use and misuse of alternative promoters in normal and disease genomes and review the molecular mechanisms regulating alternative promoter use in mammalian genomes.

引用

页码：167 / 177

页数：11

共 97 条

[1] Hypomethylation of MB-COMT promoter is a major risk factor for schizophrenia and bipolar disorder [J].

Abdolmaleky, Hamid Mostafavi ;

Cheng, Kuang-hung ;

Faraone, Stephen V. ;

Wilcox, Marsha ;

Glatt, Stephen J. ;

Gao, Fangming ;

Smith, Cassandra L. ;

Shafa, Rahim ;

Aeali, Batol ;

Carnevale, Julie ;

Pan, Hongjie ;

Papageorgis, Panagiotis ;

Ponte, Jose F. ;

Sivaraman, Vadivelu ;

Tsuang, Ming T. ;

Thiagalingam, Sam .

HUMAN MOLECULAR GENETICS, 2006, 15 (21) :3132-3145

[2] Genetics and epigenetics in major psychiatric disorders - Dilemmas, achievements, applications, and future scope [J].

Abdolmaleky, HM ;

Thiagalingam, S ;

Wilcox, M .

AMERICAN JOURNAL OF PHARMACOGENOMICS, 2005, 5 (03) :149-160

[3] Use of alternative promoters to express the aromatase cytochrome P450 (CYP19) gene in breast adipose tissues of cancer-free and breast cancer patients [J].

Agarwal, VR ;

Bulun, SE ;

Leitch, M ;

Rohrich, R ;

Simpson, ER .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1996, 81 (11) :3843-3849

[4] Ras association domain family 1C protein stimulates human lung cancer cell proliferation [J].

Amaar, Yousef G. ;

Minera, Marlon G. ;

Hatran, Laurice K. ;

Strong, Donna D. ;

Mohan, Subburaman ;

Reeves, Mark E. .

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2006, 291 (06) :L1185-L1190

[5] Alternative promoter usage of the membrane glycoprotein CD36 [J].

Andersen, Malin ;

Lenhard, Boris ;

Whatling, Carl ;

Eriksson, Per ;

Odeberg, Jacob .

BMC MOLECULAR BIOLOGY, 2006, 7

[6] Characterisation, mutation detection, and association analysis of alternative promoters and 5′ UTRs of the human dopamine D3 receptor gene in schizophrenia [J].

Anney, RJ ;

Rees, MI ;

Bryan, E ;

Spurlock, G ;

Williams, N ;

Norton, N ;

Williams, H ;

Cardno, A ;

Zammit, S ;

Jones, S ;

Jones, G ;

Hoogendoorn, B ;

Smith, K ;

Hamshere, ML ;

Coleman, S ;

Guy, C ;

O'Donovan, MC ;

Owen, MJ ;

Buckland, PR .

MOLECULAR PSYCHIATRY, 2002, 7 (05) :493-502

[7] Diversity of LEF/TCF action in development and disease [J].

Arce, L. ;

Yokoyama, N. N. ;

Waterman, M. L. .

ONCOGENE, 2006, 25 (57) :7492-7504

[8]

Archey WB, 1999, CANCER RES, V59, P2292

[9] Characterization and predictive discovery of evolutionarily conserved mammalian alternative promoters [J].

Baek, Daehyun ;

Davis, Colleen ;

Ewing, Brent ;

Gordon, David ;

Green, Phil .

GENOME RESEARCH, 2007, 17 (02) :145-155

[10] Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project [J].

Birney, Ewan ;

Stamatoyannopoulos, John A. ;

Dutta, Anindya ;

Guigo, Roderic ;

Gingeras, Thomas R. ;

Margulies, Elliott H. ;

Weng, Zhiping ;

Snyder, Michael ;

Dermitzakis, Emmanouil T. ;

Stamatoyannopoulos, John A. ;

Thurman, Robert E. ;

Kuehn, Michael S. ;

Taylor, Christopher M. ;

Neph, Shane ;

Koch, Christoph M. ;

Asthana, Saurabh ;

Malhotra, Ankit ;

Adzhubei, Ivan ;

Greenbaum, Jason A. ;

Andrews, Robert M. ;

Flicek, Paul ;

Boyle, Patrick J. ;

Cao, Hua ;

Carter, Nigel P. ;

Clelland, Gayle K. ;

Davis, Sean ;

Day, Nathan ;

Dhami, Pawandeep ;

Dillon, Shane C. ;

Dorschner, Michael O. ;

Fiegler, Heike ;

Giresi, Paul G. ;

Goldy, Jeff ;

Hawrylycz, Michael ;

Haydock, Andrew ;

Humbert, Richard ;

James, Keith D. ;

Johnson, Brett E. ;

Johnson, Ericka M. ;

Frum, Tristan T. ;

Rosenzweig, Elizabeth R. ;

Karnani, Neerja ;

Lee, Kirsten ;

Lefebvre, Gregory C. ;

Navas, Patrick A. ;

Neri, Fidencio ;

Parker, Stephen C. J. ;

Sabo, Peter J. ;

Sandstrom, Richard ;

Shafer, Anthony .

NATURE, 2007, 447 (7146) :799-816

← 1 2 3 4 5 6 7 8 9 10 →