The functional consequences of alternative promoter use in mammalian genomes

被引：289

作者：

Davuluri, Ramana V. ^{[2
]}

Suzuki, Yutaka ^{[1
]}

Sugano, Sumio ^{[1
]}

Plass, Christoph ^{[2
]}

Huang, Tim H. -M. ^{[2
]}

机构：

[1] Univ Tokyo, Dept Med Genome Sci, Grad Sch Frontier Sci, Chiba 2778562, Japan

[2] Ohio State Univ, Ctr Comprehens Canc, Human Canc Genet Program, Dept Mol Virol Immunol & Med Genet, Columbus, OH 43210 USA

来源：

TRENDS IN GENETICS | 2008年 / 24卷 / 04期

关键词：

D O I：

10.1016/j.tig.2008.01.008

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We are beginning to appreciate the increasing complexity of mammalian gene structure. A phenomenon that adds an important dimension to this complexity is the use of alternative gene promoters that drive widespread cell type, tissue type or developmental gene regulation. Recent annotations of the human genome suggest that almost one half of the protein-coding genes contain alternative promoters, including those of many disease-associated genes. Aberrant use of one promoter over another has been found to be associated with various diseases, including cancer. Here we discuss the functional consequences of use and misuse of alternative promoters in normal and disease genomes and review the molecular mechanisms regulating alternative promoter use in mammalian genomes.

引用

页码：167 / 177

页数：11

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