Instantaneous correlation of excitation and inhibition during ongoing and sensory-evoked activities

被引：463

作者：

Okun, Michael ^{[1
]}

Lampl, Ilan ^{[1
]}

机构：

[1] Weizmann Inst Sci, Dept Neurobiol, IL-76100 Rehovot, Israel

来源：

NATURE NEUROSCIENCE | 2008年 / 11卷 / 05期

基金：

以色列科学基金会;

关键词：

D O I：

10.1038/nn.2105

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Temporal and quantitative relations between excitatory and inhibitory inputs in the cortex are central to its activity, yet they remain poorly understood. In particular, a controversy exists regarding the extent of correlation between cortical excitation and inhibition. Using simultaneous intracellular recordings in pairs of nearby neurons in vivo, we found that excitatory and inhibitory inputs are continuously synchronized and correlated in strength during spontaneous and sensory-evoked activities in the rat somatosensory cortex.

引用

页码：535 / 537

页数：3

共 15 条

[1] Gain modulation from background synaptic input [J].

Chance, FS ;

Abbott, LF ;

Reyes, AD .

NEURON, 2002, 35 (04) :773-782

[2] Correlating whisker behavior with membrane potential in barrel cortex of awake mice [J].

Crochet, S ;

Petersen, CCH .

NATURE NEUROSCIENCE, 2006, 9 (05) :608-610

[3] Non-Gaussian membrane potential dynamics imply sparse, synchronous activity in auditory cortex [J].

DeWeese, Michael R. ;

Zador, Anthony M. .

JOURNAL OF NEUROSCIENCE, 2006, 26 (47) :12206-12218

[4] Shared and private variability in the auditory cortex [J].

Deweese, MR ;

Zador, AM .

JOURNAL OF NEUROPHYSIOLOGY, 2004, 92 (03) :1840-1855

[5] Somatosensory integration controlled by dynamic thalamocortical feed-forward inhibition [J].

Gabernet, L ;

Jadhav, SP ;

Feldman, DE ;

Carandini, M ;

Scanziani, M .

NEURON, 2005, 48 (02) :315-327

[6] Neocortical network activity in vivo is generated through a dynamic balance of excitation and inhibition [J].

Haider, B ;

Duque, A ;

Hasenstaub, AR ;

McCormick, DA .

JOURNAL OF NEUROSCIENCE, 2006, 26 (17) :4535-4545

[7] Inhibitory postsynaptic potentials carry synchronized frequency information in active cortical networks [J].

Hasenstaub, A ;

Shu, YS ;

Haider, B ;

Kraushaar, U ;

Duque, A ;

McCormick, DA .

NEURON, 2005, 47 (03) :423-435

[8] Synchronous membrane potential fluctuations in neurons of the cat visual cortex [J].

Lampl, I ;

Reichova, I ;

Ferster, D .

NEURON, 1999, 22 (02) :361-374

[9] Representation of tone in fluctuating maskers in the ascending auditory system [J].

Las, L ;

Stern, EA ;

Nelken, I .

JOURNAL OF NEUROSCIENCE, 2005, 25 (06) :1503-1513

[10] Spike timing, synchronization and information processing on the sensory side of the central nervous system [J].

Lestienne, R .

PROGRESS IN NEUROBIOLOGY, 2001, 65 (06) :545-591

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