Mechanisms and Consequences of Alternative Polyadenylation

被引：567

作者：

Di Giammartino, Dafne Campigli ^{[1
]}

Nishida, Kensei ^{[1
]}

Manley, James L. ^{[1
]}

机构：

[1] Columbia Univ, Dept Biol Sci, New York, NY 10027 USA

来源：

MOLECULAR CELL | 2011年 / 43卷 / 06期

关键词：

PRE-MESSENGER-RNA; 3' UNTRANSLATED REGIONS; D1 SPLICE VARIANTS; POLYMERASE-II; CYCLIN D1; MOLECULAR-MECHANISMS; POLY(A) POLYMERASE; PROCESSING FACTORS; 3'-END FORMATION; PROTEIN FACTORS;

D O I：

10.1016/j.molcel.2011.08.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Alternative polyadenylation (APA) is emerging as a widespread mechanism used to control gene expression. Like alternative splicing, usage of alternative poly(A) sites allows a single gene to encode multiple mRNA transcripts. In some cases, this changes the mRNA coding potential; in other cases, the code remains unchanged but the 3' UTR length is altered, influencing the fate of mRNAs in several ways, for example, by altering the availability of RNA binding protein sites and microRNA binding sites. The mechanisms governing both global and gene-specific APA are only starting to be deciphered. Here we review what is known about these mechanisms and the functional consequences of alternative polyadenylation.

引用

页码：853 / 866

页数：14

共 138 条

[1] SYNTHESIS OF SECRETED AND MEMBRANE-BOUND IMMUNOGLOBULIN-MU HEAVY-CHAINS IS DIRECTED BY MESSENGER-RNAS THAT DIFFER AT THEIR 3' ENDS [J].

ALT, FW ;

BOTHWELL, ALM ;

KNAPP, M ;

SIDEN, E ;

MATHER, E ;

KOSHLAND, M ;

BALTIMORE, D .

CELL, 1980, 20 (02) :293-301

[2] Distinct role of long 3′ UTR BDNF mRNA in spine morphology and synaptic plasticity in hippocampal neurons [J].

An, Juan Ji ;

Gharami, Kusumika ;

Liao, Guey-Ying ;

Woo, Newton H. ;

Lau, Anthony G. ;

Vanevski, Filip ;

Torre, Enrique R. ;

Jones, Kevin R. ;

Feng, Yue ;

Lu, Bai ;

Xu, Baoji .

CELL, 2008, 134 (01) :175-187

[3] To localize or not to localize: mRNA fate is in 3′UTR ends [J].

Andreassi, Catia ;

Riccio, Antonella .

TRENDS IN CELL BIOLOGY, 2009, 19 (09) :465-474

[4] Conservation of alternative polyadenylation patterns in mammalian genes [J].

Ara, Takeshi ;

Lopez, Fabrice ;

Ritchie, William ;

Benech, Philippe ;

Gautheret, Daniel .

BMC GENOMICS, 2006, 7 (1)

[5] Last but not least: Regulated poly(A) tail formation [J].

Barabino, SML ;

Keller, W .

CELL, 1999, 99 (01) :9-11

[6] AU-rich elements and associated factors: are there unifying principles? [J].

Barreau, C ;

Paillard, L ;

Osborne, HB .

NUCLEIC ACIDS RESEARCH, 2005, 33 (22) :7138-7150

[7] High-resolution profiling of histone methylations in the human genome [J].

Barski, Artern ;

Cuddapah, Suresh ;

Cui, Kairong ;

Roh, Tae-Young ;

Schones, Dustin E. ;

Wang, Zhibin ;

Wei, Gang ;

Chepelev, Iouri ;

Zhao, Keji .

CELL, 2007, 129 (04) :823-837

[8] Differential Interactions of the Autonomous Pathway RRM Proteins and Chromatin Regulators in the Silencing of Arabidopsis Targets [J].

Baurle, Isabel ;

Dean, Caroline .

PLOS ONE, 2008, 3 (07)

[9] Patterns of variant polyadenylation signal usage in human genes [J].

Beaudoing, E ;

Freier, S ;

Wyatt, JR ;

Claverie, JM ;

Gautheret, D .

GENOME RESEARCH, 2000, 10 (07) :1001-1010

[10] A rare polyadenylation signal mutation of the FOXP3 gene (AAUAAA→AAUGAA) leads to the IPEX syndrome [J].

Bennett, CL ;

Brunkow, ME ;

Ramsdell, F ;

O'Briant, KC ;

Zhu, Q ;

Fuleihan, RL ;

Shigeoka, AO ;

Ochs, HD ;

Chance, PF .

IMMUNOGENETICS, 2001, 53 (06) :435-439

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