An effective enantioselective approach to the securinega alkaloids:: Total synthesis of (-)-norsecurinine

被引：44

作者：

Alibés, R ^{[1
]}

Bayón, P ^{[1
]}

de March, P ^{[1
]}

Figueredo, M ^{[1
]}

Font, J ^{[1
]}

García-García, E ^{[1
]}

González-Gálvez, D ^{[1
]}

机构：

[1] Univ Autonoma Barcelona, Dept Quim, Bellaterra 08193, Spain

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 22期

关键词：

D O I：

10.1021/ol0522079

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly versatile approach to the enantioselective synthesis of securinega alkaloids is presented. Crucial steps are a palladium-catalyzed enantioselective imide alkylation, a vinylogous Mannich reaction, and a ring-closing metathesis process. Through this strategy, the synthesis of (-)-norsecurinine has been accomplished in nine steps and 11% overall yield.

引用

页码：5107 / 5109

页数：3

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