Mild and efficient copper-catalyzed N-arylation of alkylamines and N-H heterocycles using an oxime-phosphine oxide ligand

被引：139

作者：

Xu, L ^{[1
]}

Zhu, D ^{[1
]}

Wu, F ^{[1
]}

Wang, RL ^{[1
]}

Wan, BS ^{[1
]}

机构：

[1] Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China

来源：

TETRAHEDRON | 2005年 / 61卷 / 27期

关键词：

N-arylation; oxime-phosphine oxide; aryl iodides; copper; catalysis;

D O I：

10.1016/j.tet.2005.04.053

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A mild and efficient copper-catalyzed system for N-arylation of alkylamines and N-H heterocycles with aryl iodides using a novel, readily prepared and highly stable oxime-functionalized phosphine oxide ligand was developed. The coupling reactions could even be performed in solvent-free conditions with moderate to good yields. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：6553 / 6560

页数：8

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