Direct asymmetric aldol reaction in aqueous media using polymer-supported peptide

被引：115

作者：

Akagawa, K ^{[1
]}

Sakamoto, S ^{[1
]}

Kudo, K ^{[1
]}

机构：

[1] Univ Tokyo, Inst Ind Sci, Meguro Ku, Tokyo 1538505, Japan

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 47期

关键词：

peptide catalyst; direct asymmetric aldol reaction; solid support; aqueous conditions; catalyst reuse;

D O I：

10.1016/j.tetlet.2005.09.113

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

PEG-PS resin-supported tripeptide/zinc chloride catalyst system has been developed for use in the direct asymmetric aldol reaction of acetone with aldehydes in aqueous media. The peptide catalyst could be separated from the reaction mixture by filtration, and was reusable at least five times without significant change in its activity and selectivity. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：8185 / 8187

页数：3

共 43 条

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