Stem Cell Therapy: A Future Treatment of Stress Urinary Incontinence

被引：25

作者：

Nikolavasky, Dmitriy ^{[1
]}

Stangel-Wojcikiewicz, Klaudia ^{[2
]}

Stec, Malgorzata ^{[2
]}

Chancellor, Michael B. ^{[1
]}

机构：

[1] William Beaumont Hosp, Dept Urol, Royal Oak, MI 48072 USA

[2] Jagiellonian Univ Krakow, Coll Med, Dept Gynecol & Transplantol, Krakow, Poland

来源：

SEMINARS IN REPRODUCTIVE MEDICINE | 2011年 / 29卷 / 01期

关键词：

Stress urinary incontinence; muscle-derived stem cells; stem cell therapy; INTRINSIC SPHINCTER DEFICIENCY; FREE VAGINAL TAPE; MUSCLE-DERIVED CELLS; LEAK POINT PRESSURE; URETHRAL CLOSURE MECHANISMS; RANDOMIZED CONTROLLED-TRIAL; MARROW STROMAL CELLS; HUMAN ADIPOSE-TISSUE; FOLLOW-UP; RAT MODEL;

D O I：

10.1055/s-0030-1268705

中图分类号：

R71 [妇产科学];

学科分类号：

100211 [妇产科学];

摘要：

The main urinary continence mechanism in human is the striated muscle rhabdosphincter that forms a ring around the mid-urethra. Cellular therapy and the use of stem cells transplanted into the site of the rhabdosphincter in a setting of stress urinary incontinence (SUI) may augment sphincter regeneration. Implanted cells may also release trophic factors promoting muscle and nerve integration into this muscle. We review the use of cellular therapy for SUI and our experience with the development of muscle-derived stem cells.

引用

页码：61 / 69

页数：9

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