Voriconazole concentrations in the cerebrospinal fluid and brain tissue of guinea pigs and immunocompromised patients

We characterized voriconazole concentrations in the cerebrospinal fluid (CSF) of immunocompetent guinea pigs and patients with invasive fungal infections. In animals, after receipt of oral doses of 4 or 10 mg/kg every 8 h, the mean ratios of CSF to plasma total and free drug concentration were 0.68 and 1.3, respectively. In humans, 1-10 h after receipt of voriconazole, the CSF concentrations ranged from 0.08 to 3.93 mg/mL, and the ratio of CSF to plasma concentration ranged from 0.22 to 1.0 ( median, 0.46).