Voriconazole concentrations in the cerebrospinal fluid and brain tissue of guinea pigs and immunocompromised patients

被引：190

作者：

Lutsar, I ^{[1
]}

Roffey, S ^{[1
]}

Troke, P ^{[1
]}

机构：

[1] Pfizer Ltd, Sandwich CT13 9NJ, Kent, England

来源：

CLINICAL INFECTIOUS DISEASES | 2003年 / 37卷 / 05期

关键词：

D O I：

10.1086/377131

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We characterized voriconazole concentrations in the cerebrospinal fluid (CSF) of immunocompetent guinea pigs and patients with invasive fungal infections. In animals, after receipt of oral doses of 4 or 10 mg/kg every 8 h, the mean ratios of CSF to plasma total and free drug concentration were 0.68 and 1.3, respectively. In humans, 1-10 h after receipt of voriconazole, the CSF concentrations ranged from 0.08 to 3.93 mg/mL, and the ratio of CSF to plasma concentration ranged from 0.22 to 1.0 ( median, 0.46).

引用

页码：728 / 732

页数：5

共 23 条

[21] Treatment of cryptococcal meningitis associated with the acquired immunodeficiency syndrome [J].

vanderHorst, CM ;

Saag, MS ;

Cloud, GA ;

Hamill, RJ ;

Graybill, JR ;

Sobel, JD ;

Johnson, PC ;

Tuazon, CU ;

Kerkering, T ;

Moskovitz, BL ;

Powderly, WG ;

Dismukes, WE ;

Riser, L ;

Thomas, C ;

Lacke, C ;

White, AC ;

Patterson, S ;

Davis, D ;

Flanigan, C ;

Harden, T ;

Phillips, D ;

Ullom, I ;

Vasquez, J ;

McMullen, S ;

Flowers, D ;

Bosha, M ;

Britton, M ;

Fisher, JF ;

Newman, C ;

Willis, B ;

Henderson, H ;

Johnson, E ;

Dungo, L ;

Pierce, M ;

Morgan, M ;

Stern, J ;

Petrosky, N ;

Bamberger, D ;

Farnan, R ;

Feinberg, J ;

Apuzzo, L ;

Royal, W ;

Thompson, S ;

Barrett, K ;

Kauffman, C ;

Gutsch, H ;

McKinsey, D ;

Lee, B ;

Hyslop, N ;

Greenspan, D .

NEW ENGLAND JOURNAL OF MEDICINE, 1997, 337 (01) :15-21

[22] Aspergillus meningitis:: Diagnosis by non-culture-based microbiological methods and management [J].

Verweij, PE ;

Brinkman, K ;

Kremer, HPH ;

Kullberg, BJ ;

Meis, JFGM .

JOURNAL OF CLINICAL MICROBIOLOGY, 1999, 37 (04) :1186-1189

[23] Voriconazole in the treatment of aspergillosis, scedosporiosis and other invasive fungal infections in children [J].

Walsh, TJ ;

Lutsar, I ;

Driscoll, T ;

Dupont, B ;

Roden, M ;

Ghahramani, P ;

Hodges, M ;

Groll, AH ;

Perfect, JR .

PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2002, 21 (03) :240-248

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