Efficient synthesis of enantiopure 1,2-bis(hydroxymethyl)-3,3-difluorocyclopropane derivatives through lipase-catalyzed reaction

被引：28

作者：

Itoh, T ^{[1
]}

Mitsukura, K ^{[1
]}

Furutani, M ^{[1
]}

机构：

[1] Okayama Univ, Fac Educ, Dept Chem, Okayama 7008530, Japan

来源：

CHEMISTRY LETTERS | 1998年 / 09期

关键词：

D O I：

10.1246/cl.1998.903

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Efficient synthesis of chiral difluorocyclopropane building block has been accomplished; prochiral diacetate of 1,2-bis(hydroxymethyl)-3, 3-difluorocyclopropane was converted to the corresponding monoacetate through Alcaligenes sp. lipase-catalyzed hydrolysis with >99% enantiomeric excess.

引用

页码：903 / 904

页数：2

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