Exercise moderates age-related atrophy of the medial temporal lobe

被引：162

作者：

Bugg, Julie M. ^{[1
]}

Head, Denise ^{[1
]}

机构：

[1] Washington Univ, Dept Psychol, St Louis, MO 63130 USA

来源：

NEUROBIOLOGY OF AGING | 2011年 / 32卷 / 03期

关键词：

Aging; Exercise; Fitness; Brain atrophy; Hippocampus; PHYSICAL-ACTIVITY; GROWTH-FACTOR; CARDIORESPIRATORY FITNESS; COGNITIVE FUNCTION; BRAIN HEALTH; OLDER-ADULTS; NEUROGENESIS; PLASTICITY; VOLUME; YOUNG;

D O I：

10.1016/j.neurobiolaging.2009.03.008

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Regional deterioration of brain structure is a typical feature of aging, but emerging evidence suggests that exercise may mitigate the decline. The purpose of the present investigation was to examine the moderating influence of exercise engagement on cross-sectional estimates of age-related brain atrophy at both global and regional levels. Estimates of exercise engagement over the past 10 years and MRI-based measures of global (gray and white) and regional volumes were obtained in a sample of 52 healthy older adults aged 55-79. Volume estimates were obtained in prefrontal, parietal, temporal, occipital, neostriatal, and medial temporal regions. Higher levels of exercise engagement were related to larger superior frontal volumes. Most critically, exercise engagement selectively moderated age-related medial temporal lobe atrophy. Specifically, significant age-related atrophy was observed for older adults who engaged in low levels of exercise, but not for those who engaged in high levels of exercise. This novel finding extends support for the efficacy of exercise to the potential maintenance of medial temporal lobe integrity in older adults. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：506 / 514

页数：9

共 49 条

[21] An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest [J].

Desikan, Rahul S. ;

Segonne, Florent ;

Fischl, Bruce ;

Quinn, Brian T. ;

Dickerson, Bradford C. ;

Blacker, Deborah ;

Buckner, Randy L. ;

Dale, Anders M. ;

Maguire, R. Paul ;

Hyman, Bradley T. ;

Albert, Marilyn S. ;

Killiany, Ronald J. .

NEUROIMAGE, 2006, 31 (03) :968-980

[22] Physical activity and the regulation of neurogenesis in the adult and aging brain [J].

Fabel, Klaus ;

Kempermann, Gerd .

NEUROMOLECULAR MEDICINE, 2008, 10 (02) :59-66

[23] Automatically parcellating the human cerebral cortex [J].

Fischl, B ;

van der Kouwe, A ;

Destrieux, C ;

Halgren, E ;

Ségonne, F ;

Salat, DH ;

Busa, E ;

Seidman, LJ ;

Goldstein, J ;

Kennedy, D ;

Caviness, V ;

Makris, N ;

Rosen, B ;

Dale, AM .

CEREBRAL CORTEX, 2004, 14 (01) :11-22

[24] Whole brain segmentation: Automated labeling of neuroanatomical structures in the human brain [J].

Fischl, B ;

Salat, DH ;

Busa, E ;

Albert, M ;

Dieterich, M ;

Haselgrove, C ;

van der Kouwe, A ;

Killiany, R ;

Kennedy, D ;

Klaveness, S ;

Montillo, A ;

Makris, N ;

Rosen, B ;

Dale, AM .

NEURON, 2002, 33 (03) :341-355

[25] Normative estimates of cross-sectional and longitudinal brain volume decline in aging and AD [J].

Fotenos, AF ;

Snyder, AZ ;

Girton, LE ;

Morris, JC ;

Buckner, RL .

NEUROLOGY, 2005, 64 (06) :1032-1039

[26] Spatial learning and physical activity contribute to the induction of fibroblast growth factor:: Neural substrates for increased cognition associated with exercise [J].

Gómez-Pinilla, F ;

So, V ;

Kesslak, JP .

NEUROSCIENCE, 1998, 85 (01) :53-61

[27] Neuroanatomical correlates of aging, cardiopulmonary fitness level, and education [J].

Gordon, Brian A. ;

Rykhlevskaia, Elena I. ;

Brumback, Carrie R. ;

Lee, Yukyung ;

Elavsky, Steriani ;

Konopack, James F. ;

Mcauley, Edward ;

Kramer, Arthur F. ;

Colcombe, Stanley ;

Gratton, Gabriele ;

Fabiani, Monica .

PSYCHOPHYSIOLOGY, 2008, 45 (05) :825-838

[28] A Behavioral Analysis of the Impact of Voluntary Physical Activity on Hippocampus-Dependent Contextual Conditioning [J].

Greenwood, Benjamin N. ;

Strong, Paul V. ;

Foley, Teresa E. ;

Fleshner, Monika .

HIPPOCAMPUS, 2009, 19 (10) :988-1001

[29] Frontal-hippocampal double dissociation between normal aging and Alzheimer's disease [J].

Head, D ;

Snyder, AZ ;

Girton, LE ;

Morris, JC ;

Buckner, RL .

CEREBRAL CORTEX, 2005, 15 (06) :732-739

[30] Be smart, exercise your heart: exercise effects on brain and cognition [J].

Hillman, Charles H. ;

Erickson, Kirk I. ;

Kramer, Arthur F. .

NATURE REVIEWS NEUROSCIENCE, 2008, 9 (01) :58-65

← 1 2 3 4 5 →