Molecular regulation of lymphangiogenesis and targets for tissue oedema

被引：58

作者：

Karkkainen, MJ

Jussila, L

Ferrell, RE

Finegold, DN

Alitalo, K

机构：

[1] Univ Helsinki, Mol Canc Biol Lab, FIN-00014 Helsinki, Finland

[2] Univ Helsinki, Ludwig Inst Canc Res, FIN-00014 Helsinki, Finland

[3] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Human Genet, Pittsburgh, PA 15261 USA

[4] Univ Pittsburgh, Dept Pediat, Pittsburgh, PA 15213 USA

来源：

TRENDS IN MOLECULAR MEDICINE | 2001年 / 7卷 / 01期

关键词：

D O I：

10.1016/S1471-4914(00)01864-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

New insight has recently been obtained into the molecular mechanisms regulating the function of lymphatic endothelial cells. Vascular endothelial growth factors-C and -D have been shown to stimulate lymphangiogenesis. and their receptor VEGFR-3 has been linked to human hereditary lymphoedema. although there is evidence that other genes are also involved. These data suggest that it may become possible to stimulate lymphatic growth and function and to treat tissue oedema involved in many diseases.

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收藏

页码：18 / 22

页数：5

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