Enteropathogenic Escherichia coli type III effectors EspG and EspG2 disrupt the microtubule network of intestinal epithelial cells

被引：54

作者：

Shaw, RK

Smollett, K

Cleary, J

Garmendia, J

Straatman-Iwanowska, A

Frankel, G

Knutton, S

机构：

[1] Univ Birmingham, Inst Child Hlth, Birmingham B4 6NH, W Midlands, England

[2] Univ London Imperial Coll Sci Technol & Med, Ctr Mol Microbiol & Infect, Dept Biol Sci, London SW7 2AZ, England

来源：

INFECTION AND IMMUNITY | 2005年 / 73卷 / 07期

基金：

英国惠康基金;

关键词：

D O I：

10.1128/IAI.73.7.4385-4390.2005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Enteropathogenic Escherichia coli infection of intestinal epithelial cells leads to localized depletion of the microtubule cytoskeleton, an effect that is dependent on delivery of type III translocated effector proteins EspG and Orf3 (designated EspG2) to the site of depletion. Microtubule depletion involved disruption rather than displacement of microtubules.

引用

收藏

页码：4385 / 4390

页数：6

相关论文

共 26 条

[21] Identification of a novel Citrobacter rodentium type III secreted protein, EspI, and roles of this and other secreted proteins in infection [J].

Mundy, R ;

Petrovska, L ;

Smollett, K ;

Simpson, N ;

Wilson, RK ;

Yu, J ;

Tu, XL ;

Rosenshine, I ;

Clare, S ;

Dougan, G ;

Frankel, G .

INFECTION AND IMMUNITY, 2004, 72 (04) :2288-2302

[22] Characterization of Escherichia coli DNA lesions generated within J774 macrophages [J].

Schlosser-Silverman, E ;

Elgrably-Weiss, M ;

Rosenshine, I ;

Kohen, R ;

Altuvia, S .

JOURNAL OF BACTERIOLOGY, 2000, 182 (18) :5225-5230

[23] Supermolecular structure of the enteropathogenic Escherichia coli type III secretion system and its direct interaction with the EspA-sheath-like structure [J].

Sekiya, K ;

Ohishi, M ;

Ogino, T ;

Tamano, K ;

Sasakawa, C ;

Abe, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (20) :11638-11643

[24] Interaction of enteropathogenic Escherichia coli with human intestinal mucosa:: Role of effector proteins in brush border remodeling and formation of attaching and effacing lesions [J].

Shaw, RK ;

Cleary, J ;

Murphy, MS ;

Frankel, G ;

Knutton, S .

INFECTION AND IMMUNITY, 2005, 73 (02) :1243-1251

[25] Role of EscF, a putative needle complex protein, in the type III protein translocation system of enteropathogenic Escherichia coli [J].

Wilson, RK ;

Shaw, RK ;

Daniell, S ;

Knutton, S ;

Frankel, G .

CELLULAR MICROBIOLOGY, 2001, 3 (11) :753-762

[26] Shigella deliver an effector protein to trigger host microtubule destabilization, which promotes Rac1 activity and efficient bacterial internalization [J].

Yoshida, S ;

Katayama, E ;

Kuwae, A ;

Mimuro, H ;

Suzuki, T ;

Sasakawa, C .

EMBO JOURNAL, 2002, 21 (12) :2923-2935