Amphotericin B- and fluconazole-resistant Candida spp., Aspergillus fumigatus, and other newly emerging pathogenic fungi are susceptible to basic antifungal peptides

被引：112

作者：

Helmerhorst, EJ

Reijnders, IM

van't Hof, W

Simoons-Smit, I

Veerman, ECI

Amerongen, AVN

机构：

[1] Free Univ Amsterdam, Dept Oral Biochem, ACTA, NL-1081 BT Amsterdam, Netherlands

[2] Vrije Univ Amsterdam, Acad Hosp, Dept Clin Microbiol, Amsterdam, Netherlands

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1999年 / 43卷 / 03期

关键词：

D O I：

10.1128/AAC.43.3.702

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The present study shows that a number of basic antifungal peptides, including human salivary histatin 5, a designed histatin analog designated dhvar4, and a peptide from frog skin, PGLa, are active against amphotericin B-resistant Candida albicans, Candida krusei, and Aspergillus fumigatus strains and against a fluconazole-resistant Candida glabrata isolate.

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页码：702 / 704

页数：3

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