Inhibition of histone H3K9 methyltransferases by gliotoxin and related epipolythiodioxopiperazines

被引：32

作者：

Takahashi, Masanari ^{[1
,2
]}

Takemoto, Yasushi ^{[3
]}

Shimazu, Tadahiro ^{[4
]}

Kawasaki, Hisashi ^{[2
]}

Tachibana, Makoto ^{[5
]}

Shinkai, Yoichi ^{[4
,5
]}

Takagi, Motoki

Shin-ya, Kazuo ^{[6
]}

Igarashi, Yasuhiro ^{[7
]}

Ito, Akihiro ^{[1
,3
,8
]}

Yoshida, Minoru ^{[1
,3
,8
]}

机构：

[1] RIKEN, Adv Sci Inst, Chem Genet Lab, Wako, Saitama 3510198, Japan

[2] Tokyo Denki Univ, Dept Green & Sustainable Chem, Chiyoda Ku, Tokyo, Japan

[3] RIKEN, Adv Sci Inst, Chem Genom Res Grp, Wako, Saitama 3510198, Japan

[4] RIKEN, Adv Sci Inst, Cellular Memory Lab, Wako, Saitama 3510198, Japan

[5] Kyoto Univ, Inst Virus Res, Kawara, Kyoto, Japan

[6] Natl Inst Adv Ind Sci & Technol, Koto Ku, Tokyo, Japan

[7] Toyama Prefectural Univ, Biotechnol Res Ctr, Imizu, Toyama, Japan

[8] Japan Sci & Technol Corp, CREST Res Project, Kawaguchi, Saitama, Japan

来源：

JOURNAL OF ANTIBIOTICS | 2012年 / 65卷 / 05期

关键词：

epipolythiodioxopiperazine (ETP); G9a; gliotoxin; histone H3K9 methylation; histone methyltransferase (HMT); inhibitor; Suv39h1; G9A; METHYLATION; PROTEIN; CANCER; CELLS;

D O I：

10.1038/ja.2012.6

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

[No abstract available]

引用

页码：263 / 265

页数：3

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