Modifying chromatin and concepts of cancer

被引：110

作者：

Jacobson, S ^{[1
]}

Pillus, L ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Biol 0347, La Jolla, CA 92093 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1999年 / 9卷 / 02期

关键词：

D O I：

10.1016/S0959-437X(99)80027-6

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A wave of biochemical and genetic progress has identified proteins that influence transcription by modifying chromatin. Many such factors are broadly conserved and, strikingly, occur in human diseases as partners in chromosomal translocations. Understanding the function of these factors will be key to defining mechanisms of transcriptional regulation and understanding cancers linked to aberrant chromatin modification.

引用

页码：175 / 184

页数：10

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