Hyperhomocysteinaemia in treated patients with Huntington's disease

被引：24

作者：

Andrich, J ^{[1
]}

Saft, C ^{[1
]}

Arz, A ^{[1
]}

Schneider, B ^{[1
]}

Agelink, MW ^{[1
]}

Kraus, PH ^{[1
]}

Kuhn, W ^{[1
]}

Müller, T ^{[1
]}

机构：

[1] Ruhr Univ Bochum, St Josef Hosp, Dept Neurol, D-44791 Bochum, Germany

来源：

MOVEMENT DISORDERS | 2004年 / 19卷 / 02期

关键词：

homocysteine; Huntington's disease; neurodegeneration;

D O I：

10.1002/mds.10629

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Significantly increased plasma total homocysteine levels (t-Hcys) appeared in treated Huntington disease (HD) patients compared to controls and untreated HD subjects. Because the protein Huntingtin interacts with the homocysteine metabolism modulating enzyme cystathionine beta-synthase, we hypothesize that homocysteine promotes neurodegeneration in HD. (C) 2004 Movement Disorder Society

引用

页码：226 / 228

页数：3

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