Trypanothione as a target in the design of antitrypanosomal and antileishmanial agents

被引：73

作者：

Augustyns, K ^{[1
]}

Amssoms, K ^{[1
]}

Yamani, A ^{[1
]}

Rajan, PK ^{[1
]}

Haemers, A ^{[1
]}

机构：

[1] Univ Instelling Antwerp, Dept Med Chem, B-2610 Antwerp, Belgium

来源：

CURRENT PHARMACEUTICAL DESIGN | 2001年 / 7卷 / 12期

关键词：

D O I：

10.2174/1381612013397564

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Trypanothione is the key molecule in the defence mechanism of Trypanosoma and Leishmania against oxidative stress. The uniqueness of trypanothione makes the metabolism of this molecule an attractive target in antitrypanosomal and antileishmanial drug design. It became clear that this antioxidant cascade can be considered as the "Achilles heel" of these parasites. The following targets and their respective inhibitors will be discussed : biosynthesis of trypanothione with glutathionylspermidine synthetase and trypanothione synthetase; biosynthesis of glutathione with gamma -glutamylcysteine synthetase; biosynthesis of spermidine with ornithine decarboxylase; trypanothione hydroperoxide metabolism with tryparedoxine peroxidase, tryparedoxine and trypanothione reductase.

引用

页码：1117 / 1141

页数：25

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