The effect of azithromycin and clarithromycin on ex vivo interleukin-8 (IL-8) release from whole blood and IL-8 production by human alveolar macrophages

被引:37
作者
Kurdowska, A
Noble, JM
Griffith, DE
机构
[1] Univ Texas Hlth Ctr, Dept Biochem, Tyler, TX 75708 USA
[2] Univ Texas Hlth Ctr, Dept Med, Tyler, TX 75708 USA
关键词
D O I
10.1093/jac/47.6.867
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
We investigated the effects of azithromycin and clarithromycin, two antibiotics that possess a broad spectrum of antimicrobial activity (including antimycobacterial activity), on interleukin-8 (IL-8) release from human whole blood leucocytes and lung macrophages. Ex vivo stimulation of leukocytes with either of the antibiotics (0.04-40 mg/L) significantly increased IL-8 secretion. Incubation of alveolar macrophages with different concentrations of azithromycin or clarithromycin modified IL-8 production: it increased at a drug concentration of 4 mg/L and decreased at concentration of 400 mg/L. Our findings suggest that azithromycin and clarithromycin may alter IL-8 production, thus enhancing the clinical effectiveness of these antibiotics.
引用
收藏
页码:867 / 870
页数:4
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