Immune system versus tumor: shifting the balance in favor of DCs and effective immunity

被引：45

作者：

Kaufman, HL

Disis, ML

机构：

[1] Columbia Univ, Med Ctr, Dept Surg, New York, NY 10032 USA

[2] Univ Washington, Tumor Vaccine Grp, Seattle, WA USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2004年 / 113卷 / 05期

关键词：

D O I：

10.1172/JCI200421148

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Despite the initial excitement over cancer vaccines, the clinical effectiveness of immunotherapy has been disappointing. The suppressive milieu present within established tumors inhibits effective immune responses, although new strategies are emerging to manipulate the local tumor microenvironment and shift the balance back to a proinflammatory environment, promote DC activation, and enhance tumor immunity (see the related article beginning on page 774).

引用

收藏

页码：664 / 667

页数：4

相关论文

共 16 条

[1] Cancer vaccines: Between the idea and the reality [J].

Finn, OJ .

NATURE REVIEWS IMMUNOLOGY, 2003, 3 (08) :630-641

[2] Induction of potent antitumor immunity by in situ targeting of intraturnoral DCs [J].

Furumoto, K ;

Soares, L ;

Engleman, EG ;

Merad, M .

JOURNAL OF CLINICAL INVESTIGATION, 2004, 113 (05) :774-783

[3] Tumor rejection and immune memory elicited by locally released LEC chemokine are associated with an impressive recruitment of APCs, lymphocytes, and granulocytes [J].

Giovarelli, M ;

Cappello, P ;

Forni, G ;

Salcedo, T ;

Moore, PA ;

LeFleur, DW ;

Nardelli, B ;

Di Carlo, E ;

Lollini, PL ;

Ruben, S ;

Ullrich, S ;

Garotta, G ;

Musiani, P .

JOURNAL OF IMMUNOLOGY, 2000, 164 (06) :3200-3206

[4] A controlled trial of a human papillomavirus type 16 vaccine [J].

Koutsky, LA ;

Ault, KA ;

Wheeler, CM ;

Brown, DR ;

Barr, E ;

Alvarez, FB ;

Chiacchierini, LM ;

Jansen, KU .

NEW ENGLAND JOURNAL OF MEDICINE, 2002, 347 (21) :1645-1651

[5] Prevalence of regulatory T cells is increased in peripheral blood and tumor microenvironment of patients with pancreas or breast adenocarcinoma [J].

Liyanage, UK ;

Moore, TT ;

Joo, HG ;

Tanaka, Y ;

Herrmann, V ;

Doherty, G ;

Drebin, JA ;

Strasberg, SM ;

Eberlein, TJ ;

Goedegebuure, PS ;

Linehan, DC .

JOURNAL OF IMMUNOLOGY, 2002, 169 (05) :2756-2761

[6] Tumors as elusive targets of T-cell-based active immunotherapy [J].

Marincola, FM ;

Wang, E ;

Herlyn, M ;

Seliger, B ;

Ferrone, S .

TRENDS IN IMMUNOLOGY, 2003, 24 (06) :335-342

[7] Dendritic cell maturation in active immunotherapy strategies [J].

Morse, MA ;

Mosca, PJ ;

Clay, TM ;

Lyerly, HM .

EXPERT OPINION ON BIOLOGICAL THERAPY, 2002, 2 (01) :35-43

[8] Lymphocyte traffic control by chemokines [J].

Moser, B ;

Loetscher, P .

NATURE IMMUNOLOGY, 2001, 2 (02) :123-128

[9] Does the immune system see tumors as foreign or self? [J].

Pardoll, D .

ANNUAL REVIEW OF IMMUNOLOGY, 2003, 21 :807-839

[10] Immunity to melanoma: unraveling the relation of tumor immunity and autoimmunity [J].

Ramirez-Montagut, T ;

Turk, MJ ;

Wolchok, JD ;

Guevara-Patino, JA ;

Houghton, AN .

ONCOGENE, 2003, 22 (20) :3180-3187