Efficient fluorescein spirolactam and bis-spirolactam synthesis

被引：20

作者：

Adamczyk, M ^{[1
]}

Grote, J ^{[1
]}

机构：

[1] Abbott Labs, Div Diagnost, Dept Chem D9NM, Abbott Pk, IL 60064 USA

来源：

SYNTHETIC COMMUNICATIONS | 2001年 / 31卷 / 17期

关键词：

D O I：

10.1081/SCC-100105396

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reaction of fluorescein methyl ester at ambient temperature with a variety of amines containing different functional groups afforded a family of spirolactams, the structures of which were verified by MS, NMR, and x-ray crystallography. Bis-spirolactams were prepared by subsequent reaction of an aminospirolactam with another molecule of fluorescein methyl ester.

引用

页码：2681 / 2690

页数：10

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