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Oxidants and antioxidants in the pathogenesis of atherosclerosis: implications for the oxidized low density lipoprotein hypothesis

被引：392
作者：
Heinecke, JW
机构：
[1] Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA
[2] Washington Univ, Sch Med, Dept Mol Biol & Pharmacol, St Louis, MO 63110 USA
来源：
ATHEROSCLEROSIS | 1998年 / 141卷 / 01期
关键词：
atherosclerosis; low density lipoproteins; oxidation; myeloperoxidase; lipoxygenase; atherogenesis;
D O I：
10.1016/S0021-9150(98)00173-7
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The oxidation hypothesis proposes that low density lipoprotein must be oxidatively modified to trigger the pathological events of atheroscleosis. In this article, we evaluate recent studies addressing the pathways that promote low density lipoprotein oxidation in vivo and the impact of antioxidants on atherogenesis in animals, paying particular attention to the clinical implications of these studies for the oxidation hypothesis. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.
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页码：1 / 15
页数：15
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