Synthesis of fused tricyclic beta-lactams by the Pauson-Khand cyclization of enyne-2-azetidinones

被引：14

作者：

Alcaide, B ^{[1
]}

Polanco, C ^{[1
]}

Sierra, MA ^{[1
]}

机构：

[1] UNIV COMPLUTENSE MADRID,FAC QUIM,DEPT QUIM ORGAN 1,MADRID 28040,SPAIN

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 38期

关键词：

D O I：

10.1016/0040-4039(96)01511-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reaction of enyne-beta-lactams 1 with Co-2(CO)(8) followed by in situ thermal or TMANO decomposition of the formed alkyne-Co-2(CO)(6) complexes gives tricyclic beta-lactams 2 as single stereoisomers, in good to excellent yields. These are the first examples of an intramolecular Pauson-Khand reaction on an enyne system tethered to a four membered ring. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：6901 / 6904

页数：4

共 37 条

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