A novel traceless solid phase tertiary amine synthesis based on Merrifield resin

被引：17

作者：

Cai, JQ ^{[1
]}

Wathey, B ^{[1
]}

机构：

[1] Organon Labs Ltd, Lead Discovery Unit, Newhouse ML1 5SH, Lanark, Scotland

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 07期

关键词：

tertiary amine; traceless linker; solid phase synthesis;

D O I：

10.1016/S0040-4039(00)02251-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Substitution of Merrifield resin by a secondary amine gives a resin-bound tertiary amine which is then quaternised with an alkyl halide to provide a resin-bound quaternary ammonium salt. Cleavage of the ammonium salt with morpholine delivers a tertiary amine ill high yield and purity. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：1383 / 1385

页数：3

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